Opthea Ltd — Major Shareholding Notification 2022

Jun 6, 2022

	To Company Name/SchemeACN/ARSN1. Details of substantial holder (1)Name Form 604Corporations Act 2001Section 671BNotice of change of interests of substantial holderOPTHEA LTD (OPT)006 340 567Regal Funds Management Pty Limited and its(see Annexure 1)	To Company Name/SchemeACN/ARSN1. Details of substantial holder (1)Name Form 604Corporations Act 2001Section 671BNotice of change of interests of substantial holderOPTHEA LTD (OPT)006 340 567Regal Funds Management Pty Limited and its(see Annexure 1)	To Company Name/SchemeACN/ARSN1. Details of substantial holder (1)Name Form 604Corporations Act 2001Section 671BNotice of change of interests of substantial holderOPTHEA LTD (OPT)006 340 567Regal Funds Management Pty Limited and its(see Annexure 1)	To Company Name/SchemeACN/ARSN1. Details of substantial holder (1)Name Form 604Corporations Act 2001Section 671BNotice of change of interests of substantial holderOPTHEA LTD (OPT)006 340 567Regal Funds Management Pty Limited and its(see Annexure 1)	To Company Name/SchemeACN/ARSN1. Details of substantial holder (1)Name Form 604Corporations Act 2001Section 671BNotice of change of interests of substantial holderOPTHEA LTD (OPT)006 340 567Regal Funds Management Pty Limited and its(see Annexure 1)	associates	associates
	ACN/ARSN (if applicThe previous noticeThe previous notice2. Previous and pr*The % substantial i3. Changes in relORDINARYParticulars of each chasince the substantial hoADS each represenordinary shareThe total number of votinterest (3) in when lasThere was a changeClass of securities	able)was given to the company onwas datedesent voting powers based on the shares on issue of 352,152,54evant interestsnge in, or change in the nature of, a relevant intereslder was last required to give a substantial holding n44,262,448ting 8s2,883,302es attached to all the voting shares in the companyt required, and when now required, to give a substanin the interests of the substantial holder on(4)Person's votesPrevious notice		-2 as disclosed by tht of the substantial holdeotice to the company or 12.58% 6.55%or voting interests in thetial holding notice to theVoting power (5)	3/06/202216/05/202212/05/2022e Company on 27-05-2022.r or an associate in voting securitiesscheme are as follows:43,701,0222,883,790scheme that the substantial holder ocompany or scheme, are as followCurrentPerson's votes	Class andnumber ofsecuritiesPerson'svotes20,899,773Ordinary20,889,773 of the company or scheme,*12.41%*6.55%r an associate (2) had a relevants:noticeVoting power (5)nd number of securities
	Holder of relevant in	terest	Date of acquisitionSee Annexure 2	Considera	tion (9)Class a	nd number of securities
	4. Present relevanParticulars of each r	t inteeleva	restsnt interest of the substantial holder in voting securities after t		he change are as follows:
	Holder of relevant intUBS AG, Australia Br	erestanch	Registered holder of securitiesUBS Nominees Pty LtdPerson entitledhoUBS AG, A		Nature ofrelevantinterest (6)to be registered aslder (8)ustralia BranchHOLDER OFSHARES	Class andnumber ofsecuritiesPerson'svotes20,899,773Ordinary20,889,773
	Morgan Stanley & Co Intl PlcMerrill Lynch InternationalLimitedJ.P MORGAN SECURITIESPLCCredit Suisse AG		UBS Securities LLC & CitibankMerrill Lynch Pierce Fenner & SmithMerrill Lynch (Australia) Nominees Pty LimitedHSBC Custody Nominees (Australia) Limited A/C 2Morgan StaMerrill Lynch IJ.P. MORGAN PRIME NOMINEES LTDJ.P MORGANCS Third Nominees Pty LtdCredit		HOLDER OFSHARESHOLDER OFSHARESHOLDER OFSHARESnley & Co Intl Plcnternational LimitedHOLDER OFSHARESSECURITIES PLCSuisse AG	440,637ADS3,525,096 1,286,776Ordinary1,286,77613,976,823Ordinary13,976,8232,443,153ADS19,545,224 3,091,085Ordinary3,091,0854,456,565Ordinary4,456,565
	5. Changes in associatiThe persons who have besubstantial holder in relati		oncome associates (2) of, ceased to be associates of, or havon to voting interests in the company or scheme are as follow		e changed the nature of their ass:
	Name aREG		nd ACN/ARSN (if applicable)AL PARTNERS LIMITED100% OWN		Nature of associationER OF REGAL FUNDS MANALIMITED	GEMENT PTY

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----- Start of picture text ----- Previous notice Current noticeClass of securities (4)Person's votes Voting power (5) Person's votes Voting power (5)ORDINARY 44,262,448 12.58% 43,701,022 *12.41%ADS each representing 8 2,883,302 6.55% 2,883,790 *6.55%ordinary shares----- End of picture text -----

Holder	of	relevant	interest	Date of acquisition	Consideration (9)	Class and number of securities
				See Annexure 2

Holder of relevant interest	Registered holder of securities	Person entitled to be registered asholder (8)	Nature ofrelevantinterest (6)	Class andnumber ofsecurities	Person'svotes
UBS AG, Australia Branch	UBS Securities LLC & CitibankUBS Nominees Pty Ltd	UBS AG, Australia Branch	HOLDER OFSHARES	20,899,773Ordinary440,637ADS	20,889,773 3,525,096
Morgan Stanley & Co Intl Plc	HSBC Custody Nominees (Australia) Limited A/C 2	Morgan Stanley & Co Intl Plc	HOLDER OFSHARES	1,286,776Ordinary	1,286,776
Merrill Lynch InternationalLimited	Merrill Lynch Pierce Fenner & SmithMerrill Lynch (Australia) Nominees Pty Limited	Merrill Lynch International Limited	HOLDER OFSHARES	13,976,823Ordinary2,443,153ADS	13,976,823 19,545,224
J.P MORGAN SECURITIESPLC	J.P. MORGAN PRIME NOMINEES LTD	J.P MORGAN SECURITIES PLC	HOLDER OFSHARES	3,091,085Ordinary	3,091,085
Credit Suisse AG	CS Third Nominees Pty Ltd	Credit Suisse AG	HOLDER OFSHARES	4,456,565Ordinary	4,456,565

Name and ACN/ARSN (if applicable)		Nature of association
REGAL PARTNERS LIMITED	100% OWNER OF REGAL FUNDS MANAGEMENT PTY
		LIMITED

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----- Start of picture text ----- 6. AddressesThe addresses of persons named in this form are as follows:Name AddressLEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEYREGAL FUNDS MANAGEMENT PTY LIMITEDNSW 2000LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEYREGAL PARTNERS LIMITEDNSW 2000Signatureprint name Kenny Ho capacity Company Secretarysign here date 7/06/2022Annexure 1 Details of Substantial HoldersACN Name107 576 821 REGAL FUNDS MANAGEMENT PTY LIMITED129 188 450 REGAL PARTNERS LIMITEDAnnexure 2 Changes in relevant interests [ordinary]Considerationgiven in Number of PersonsNature of relation to securities Class of votesDate Person whose relevant interest changed Change change affected securities affectedRegal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty16/05/2022 Limited) Buy 79619.79 66505 Ordinary 66505Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty17/05/2022 Limited) Sell 378000.00 300000 Ordinary 300000Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty17/05/2022 Limited) Buy 75984.00 60000 Ordinary 60000Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty18/05/2022 Limited) Buy 23220.00 18000 Ordinary 18000Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty20/05/2022 Limited) Sell 719790.06 521587 Ordinary 521587Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty23/05/2022 Limited) Buy 21280.00 16000 Ordinary 16000Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty24/05/2022 Limited) Buy 53546.54 40991 Ordinary 40991Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty31/05/2022 Limited) Buy 54700.00 40000 Ordinary 40000Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty1/06/2022 Limited) Buy 24495.95 18665 Ordinary 18665 Changes in relevant interests [ADS]Regal Funds Management Pty Limited (and Regal PartnersLimited by virtue of control of Regal Funds Management Pty31/05/2022 Limited) Buy 3793.47 488 ADS 488Regal Partners Limited now has a relevant interest in the interests held by Regal Funds Management Pty Limited as a result of the recent acquisition of RegalFunds Management Pty Limited by Regal Partners Limited.----- End of picture text -----