Opthea Ltd — Major Shareholding Notification 2022

Oct 4, 2022

Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder	Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder	Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder	Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder	Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder	Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder
To Company Name/Scheme ACN/ARSN 1. Details of substantial holder (1) Name ACN/ARSN (if applicable) The previous notice was given to the compa The previous notice was dated 2. Previous and present voting power The total number of votes attached to all the voting (3) in when last required, and when now required, t There was a change in the interests of the s	ny on shares in the company or voting interests in o give a substantial holding notice to the com ubstantial holder on	OPTHEA L		TD (OPT)
		006 340 56		7
		Regal Fund (see Annex		s Management Pty Limited ure 1)		and its associates
		-
		the scheme that pany or schem		3/10/2022 29/08/2022 25/08/2022 the substantial holder or an assoc e, are as follows:		Class and number of securities Person's votes 34,610,825 Ordinary 34,610,825 1,240,985 ADS 9,927,880 1,786,776 Ordinary 1,786,776 21,756,482 Ordinary 21,756,482 1,343,153 ADS 10,745,224 9,873,686 Ordinary 9,873,686 300,000 ADS 2,400,000 (9) with, the substantial pany or scheme, since the 14.64% 4.96% iate (2) had a relevant interest notice Voting power (5) NAGEMENT d number of securities
Class of securities (4)	Previous notice			Current		notice
	Person's votes	Voting power (5)		Person's votes		Voting power (5)
ORDINARY	49,319,603	12.18%		68,027,769		*14.64%
ADS each representing 8 ordinary shares	2,883,790	5.70%		2,884,138		*4.96%
The % substantial is based on the shares o 3. Changes in relevant interests* Particulars of each change in, or change in the nat substantial holder was last required to give a subst	n issue of 464,771,608 as disclosed by the Company on 30-09-2022. ure of, a relevant interest of the substantial holder or an associate in voting securities of the com antial holding notice to the company or scheme are as follows:
Holder of relevant interest	Date of acquisition	Consideration (9)			Class an	d number of securities
	See Annexure 2
4. Present relevant interests Particulars of each relevant interest of the su	bstantial holder in voting securities after the change are as follows:
Holder of relevant interest	Registered holder of securities		Person entitled to be registered as holder (8)		Nature of relevant interest (6)	Class and number of securities	Person's votes
Regal Funds Management Pty Ltd and its associates	UBS Nominees Pty Ltd		UBS AG, Australia Branch		HOLDER OF SHARES	34,610,825 Ordinary	34,610,825
	UBS Securities LLC & Citibank					1,240,985 ADS	9,927,880
Regal Funds Management Pty Ltd and its associates	HSBC Custody Nominees (Australia) Limited A/C 2		Morgan Stanley & Co Intl Plc		HOLDER OF SHARES	1,786,776 Ordinary	1,786,776
Regal Funds Management Pty Ltd and its associates	Merrill Lynch (Australia) Nominees Pty Limited		Merrill Lynch International Limited		HOLDER OF SHARES	21,756,482 Ordinary	21,756,482
	Merrill Lynch Pierce Fenner & Smith					1,343,153 ADS	10,745,224
Regal Funds Management Pty Ltd and its associates	J.P. MORGAN PRIME NOMINEES LTD		J.P. MORGAN SECURITIES PLC		HOLDER OF SHARES	9,873,686 Ordinary	9,873,686
	J.P. MORGAN SECURITIES LLC		J.P. MORGAN SECURITIES LLC			300,000 ADS	2,400,000
5. Changes in association The persons who have become associates holder in relation to voting interests in the co	(2) of, ceased to be associates of, or have changed the nature of their association mpany or scheme are as follows:
Name and ACN/AR	SN (if applicable)		Nature of association
REGAL PARTN	ERS LIMITED		100% OWNER OF REGAL FUNDS MA PTY LIMITED			NAGEMENT

	Previous notice		Current notice	Current notice
Class of securities (4)	Person's votes	Voting power (5)	Person's votes		Voting power (5)
ORDINARY	49,319,603	12.18%	68,027,769		*14.64%
ADS each representing 8 ordinary shares	2,883,790	5.70%	2,884,138		*4.96%

Holder of relevant interest	Date of acquisition		Consideration (9)	Class and number of securities	Class and number of securities	Class and number of securities
	See Annexure 2
4. Present relevant interests
Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:
Holder of relevant interest	Registered holder of securities		Person entitled to be registered as holder (8)	Nature of relevant interest (6)	Class and number of securities	Person's votes
Regal Funds Management Pty Ltd and its associates	UBS Securities LLC & Citibank UBS Nominees Pty Ltd		UBS AG, Australia Branch	HOLDER OF SHARES	34,610,825 Ordinary 1,240,985 ADS	34,610,825 9,927,880
Regal Funds Management Pty Ltd and its associates	HSBC Custody Nominees (Australia) Limited A/C 2		Morgan Stanley & Co Intl Plc	HOLDER OF SHARES	1,786,776 Ordinary	1,786,776
Regal Funds Management Pty Ltd and its	Merrill Lynch (Australia) Nominees Pty Limited		Merrill Lynch International	HOLDER OF	21,756,482 Ordinary	21,756,482
associates	Merrill Lynch Pierce Fenner & Smith		Limited	SHARES	1,343,153 ADS	10,745,224
Regal Funds Management Pty Ltd and its	J.P. MORGAN PRIME NOMINEES LTD		J.P. MORGAN SECURITIES PLC	HOLDER OF	9,873,686 Ordinary	9,873,686
associates				SHARES
	J.P. MORGAN SECURITIES LLC		J.P. MORGAN SECURITIES LLC		300,000 ADS	2,400,000

Name and ACN/ARSN (if applicable)	Nature of association
REGAL PARTNERS LIMITED	100% OWNER OF REGAL FUNDS MANAGEMENT
	PTY LIMITED

6. Addresses The addresses of persons named in this form are as follo	6. Addresses The addresses of persons named in this form are as follo	ws: capacity CompanySecretary Address LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000 KennyHo LIMITED LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000	ws: capacity CompanySecretary Address LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000 KennyHo LIMITED LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000	ws: capacity CompanySecretary Address LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000 KennyHo LIMITED LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000	ws: capacity CompanySecretary Address LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000 KennyHo LIMITED LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000	ws: capacity CompanySecretary Address LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000 KennyHo LIMITED LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000	ws: capacity CompanySecretary Address LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000 KennyHo LIMITED LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000
Name			Address
REGAL FUNDS MANAGEMENT PTY		LIMITED	LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000
REGAL PARTNERS LIMITED			LEVEL 47, GATEWAY, 1 MACQUARIE PLACE, SYDNEY NSW 2000
Signature print name sign here Annexure 1 Details of Substantial Holders
		date 5/10/2022
		Nature of Change Consideration given in relation to change Number of securities affected Class of securities Persons votes affected Sell 363273.75 322910 Ordinary 322910 Buy 363273.75 322910 Ordinary 322910 Buy 11942.34 10659 Ordinary 10659 Buy 70328.25 62514 Ordinary 62514 Buy 552518.40 493320 Ordinary 493320 Buy 288125.00 250000 Ordinary 250000 Buy 63974.54 56819 Ordinary 56819 Buy 44720.00 40000 Ordinary 40000 Buy 57968.72 50896 Ordinary 50896 Buy 175500.00 150000 Ordinary 150000 Buy 27480.00 24000 Ordinary 24000 Buy 131969.05 113179 Ordinary 113179 Buy 20042507.05 17428267 Ordinary 17428267 Buy 33102.43 28512 Ordinary 28512 egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) rest changed egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) egal Partners Limited by virtue ment Pty Limited) TED egal Partners Limited by virtue ment Pty Limited)
ACN	Name
107 576 821	REGAL FUNDS MANAGEMENT PTY LIMI	TED
129 188 450	REGAL PARTNERS LIMITED
Annexure 2 Changes in relevant interests [ordinary]
Date	Person whose relevant inte	rest changed	Nature of Change	Consideration given in relation to change	Number of securities affected	Class of securities	Persons votes affected
1/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Sell	363273.75	322910	Ordinary	322910
1/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	363273.75	322910	Ordinary	322910
1/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	11942.34	10659	Ordinary	10659
2/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	70328.25	62514	Ordinary	62514
14/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	552518.40	493320	Ordinary	493320
19/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	288125.00	250000	Ordinary	250000
28/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	63974.54	56819	Ordinary	56819
28/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	44720.00	40000	Ordinary	40000
29/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	57968.72	50896	Ordinary	50896
30/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	175500.00	150000	Ordinary	150000
30/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	27480.00	24000	Ordinary	24000
30/09/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	131969.05	113179	Ordinary	113179
3/10/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	20042507.05	17428267	Ordinary	17428267
3/10/2022	Regal Funds Management Pty Limited (and R of control of Regal Funds Manage	egal Partners Limited by virtue ment Pty Limited)	Buy	33102.43	28512	Ordinary	28512

Changes in relevant interests [ADS]	Changes in relevant interests [ADS]	Changes in relevant interests [ADS]	Changes in relevant interests [ADS]	Changes in relevant interests [ADS]	Changes in relevant interests [ADS]	Changes in relevant interests [ADS]
29/09/2022	Regal Funds Management Pty Limited (and Regal Partners Limited by virtue of control of Regal Funds Management Pty Limited)	Buy	1565.09	261	Ordinary	261
30/09/2022	Regal Funds Management Pty Limited (and Regal Partners Limited by virtue of control of Regal Funds Management Pty Limited)	Buy	530.70	87	Ordinary	87