Opthea Ltd — Major Shareholding Notification 2018

May 10, 2018

Form 605

Corporations Act 2001

Section 671B

Notice of ceasing to be a substantial holder

To Company Name/Scheme Antisense Therapeutics Limited (ANP)

ACN/ARSN 095 060 745

1. Details of substantial holder

Name Opthea Limited

ACN/ARSN (if applicable) 006 340 567

The holder ceased to be a substantial holder on 9/May/2018

The previous notice was given to the company on 16/May/2016

The previous notice was dated 11/May/2016

2. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

Date of change	Person whoserelevant interestchanged	Nature of change	Considerationgiven in rela-tion to change	Class and num-ber of securitiesaffected	Person’svotes affected
9 May 2018	Opthea Limited	Dilution: ANP share issues totalling195,074,155 between 19 December 2016and 9 May 2018.	N/A	N/A	N/A

3. Changes in association

The persons who have become associates of, ceased to be associates of, or have changed the nature of their association with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Name and ACN/ARSN (if applicable)	Nature of association
Not applicable

4. Addresses

The addresses of persons named in this form are as follows:

The addresses of persons named in this	form are as follows:
Name	Address
Opthea Limited	Suite 0403, Level 4, 650 Chapel Street, South Yarra, VIC 3141, Australia

Signature

ure
print namesign here	Mike TonroecapacityCompany Secretary
	date11/May/2018