Opthea Ltd — Major Shareholding Notification 2016

May 15, 2016

Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

To: ANTISENSE THERAPEUTICS LIMITED (ANP)

ACN: 095 060 745

1. Details of substantial holder

Name: Opthea Limited ACN: 006 340 567 (formerly Circadian Technologies Limited) and its related bodies corporate.

There was a change in the interests of the substantial holder on: 11 May 2016

The previous notice was given to the company on: 17 November 2014

The previous notice was dated: 17 November 2014

2. Previous and present voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate had a relevant interest in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows:

	Previous notice	Previous notice	Present	notice
Class of securities	Person’s votes	Voting power	Person’s votes	Voting power
Ordinary	14,361,583	8.89%	10,190,649	5.77%

3.

Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

See Annexure ‘A’ .

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Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

follows:	follows:
Holder of relevantinterest		Registered holderof securities	Person entitled tobe registered asholder	Nature ofrelevantinterest		Class andnumber ofsecurities	Person’svotes
PolychipPharmaceuticalsPty LtdACN 066455 456_( wholly_owned by OptheaLimited)							10,190,649
	uticalsCN 066hll	PolychipPharmaceuticals PtyLtd	PolychipPharmaceuticalsPty Ltd	BeneOwn	ficialer	Ordinaryshares10190649	101906
	oypthea					,,	,,
	nges in association

5. Changes in association

The persons who have become associates of, ceased to be associates of, or have changed the nature of their association with, the substantial holder in relation to voting interests in the company or scheme are as follows:

follows:
Name and ACN (if applicable)	Nature of association
Not applicable

6. Addresses

The addresses of persons named in this form are as follows:

Name	Address (Registered Office)
Opthea Limited(Opthea)	Suite 0403 650 Chapel Street,South Yarra,VIC 3141
PolychipPharmaceuticals PtyLtd (Polychip)	Suite 0403 650 Chapel Street,South Yarra VIC 3141
Syngene Limited(In Liquidation) (Syngene)	L8,179Queen Street,Melbourne VIC 3000

Signed by:

==> picture [105 x 50] intentionally omitted <==

Mike Tonroe Company Secretary 16 May 2016

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Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

ANNEXURE A: CHANGES IN RELEVANT INTERESTS

ANTISENSE THERAPEUTICS LIMITED (ASX:ANP)

Date ofchange	Person whose relevantinterest changed	Nature of change(ordinary shares)	Considerationgiven inrelation tochange	Class andnumber ofsecuritiesaffected(ordinaryshares)	Person’svotesaffected(no. ofshares)
15-05-2015	Polychip & Syngene	Dilution: 15,025,075shares issued	N/A	Number ofordinaryshares notaffected	Number ofvotes/sharesnot affected
20-10-2015	Syngene	On market sale	$4,151	46,121	46,121
16-11-2015	Syngene	On market sale	$8,302	92,242	92,242
17-11-2015	Syngene	On market sale	$1,052	11,694	11,694
11-05-2016	Syngene	Private sale -liquidation ofsubsidiary	$160,835	4,020,877	4,020,877

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