Opthea Ltd — Major Shareholding Notification 2014

Nov 13, 2014

Form 604 Corporations Act 2001 Section 671B

Notice of change of interests of substantial holder

To Company Name/Scheme:

Circadian Technologies Ltd

ACN/ARSN

006 340 567

1. Details of substantial shareholder

Name

Deutsche Bank AG and its related bodies corporate (together, the “Deutsche Bank Group”)

ACN/ARSN (if applicable)

064 165 162

There was a change in the interests of the substantial holder on 12 November 2014

The previous notice was given to the company on 24 October 2014 The previous notice was dated 22 October 2014

2. Previous and present voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows:

Class of securities (4)	Previous notice	Previous notice	Present notice	Present notice
	Person’s votes	Voting power(5)	Person’s votes	Voting power(5)
Ordinary shares	6,857,143	12.36%	6,857,143	9.15%

3. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

Date of change	Person whose relevant interest changed	Nature of change (6)	Consideration given in relation to change (7)	Class and number of securities affected (Ordinary shares)	Person’s votes affected
12 Nov 14	Deutsche Asset & Wealth Management Investment GmbH	Change in Quoted Shares On Issue	N/A	6,857,143	6,857,143

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

Holder of relevant interest	Registered holder of securities	Person entitled to be registered as holder (8)	Nature of relevant interest (6)	Class and number of securities (Ordinary shares)	Person’s Votes
Deutsche Asset & Wealth Management Investment GmbH	State Street Bank GmbH	Deutsche Asset & Wealth Management Investment GmbH	Power to dispose of, or control the exercise of a power to dispose of, the securities held in capacity as investment manager	6,857,143	6,857,143

5. Changes in association

The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Name and ACN/ARSN (if applicable)	Nature of association
N/A.

6. Addresses

The addresses of persons named in this form are as follows:

Name	Address
Deutsche Asset & Wealth Management Investment GmbH	Mainzer Landstraße 178-190, Frankfurt, Hessen, Germany 60327

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Signature

Name Carmen Chan Deutsche Bank AG, Hong Kong Branch 14 November 2014