Opthea Ltd — Major Shareholding Notification 2014

Nov 16, 2014

Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

To: ANTISENSE THERAPEUTICS LIMITED (ANP)

ACN: 095 060 745

1. Details of substantial holder

Name:

Circadian Technologies Limited (ACN:006 340 567) and its related bodies corporate.

There was a change in the interests of the substantial holder on: 12/11/2014 The previous notice was given to the company on: 17/07/2012 The previous notice was dated: 17/07/2012

2. Previous and present voting power

The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate had a relevant interest in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows:

Class of securities	Previous notice	Previous notice	Present notice	Present notice
	Person’s votes	Voting power	Person’s votes	Voting power
Ordinary	143,149,187	11.03%	14,361,583	8.89%

3. Changes in relevant interests

Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows:

See Annexure ‘A’.

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Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

4. Present relevant interests

Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows:

follows:
Holder of relevant interest	Registered holder of securities	Person entitled to be registered as holder	Nature of relevant interest	Class and number of securities	Person’s votes
Polychip Pharmaceuticals Pty LtdACN 066 455 456_( wholly_ owned by Circadian Technologies Ltd)	Polychip Pharmaceuticals Pty Ltd	Polychip Pharmaceuticals Pty Ltd	Beneficial Owner	Ordinary shares 10,190,649	10,190,649
Syngene Limited ACN 006 161 753 (A 51.7% owned and controlled entity of Circadian Technologies Ltd)	Syngene Limited	Syngene Limited	Beneficial Owner	Ordinary shares 4,170,934	4,170,934

5. Changes in association

The persons who have become associates of, ceased to be associates of, or have changed the nature of their association with, the substantial holder in relation to voting interests in the company or scheme are as follows:

Name and ACN (ifapplicable)	**Nature of association **
Not applicable

6. Addresses

The addresses of persons named in this form are as follows:

Name	Address (Registered Office)
Circadian Technologies Limited(Circadian)	Suite 0403 650 Chapel Street,South Yarra. 3141
PolychipPharmaceuticals PtyLtd (Polychip)	Suite 0403 650 Chapel Street,South Yarra. 3141
Syngene Limited(Syngene)	Suite 0403 650 Chapel Street,South Yarra. 3141

Signed by:

==> picture [105 x 51] intentionally omitted <==

Mike Tonroe Company Secretary 17 November 2014

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Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

ANNEXURE A: CHANGES IN RELEVANT INTERESTS

ANTISENSE THERAPEUTICS LIMITED (ASX:ANP)

Date of change	Person whose relevant interest changed	Nature of change (ordinary shares)	Consideration given in relation to change	Class and number of securities affected (ordinary shares)	Person’s votes affected (no. of shares)
17-07-2012	Syngene	Exercise of options	$18,333	1,666,655	1,666,655
24-07-2012	Polychip & Syngene	Dilution: 3,000,000 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected
24-07-2012	Polychip & Syngene	Dilution: 22,818,054 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected
02-08-2012	Polychip & Syngene	Dilution: 114,052,957 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected
03-08-2012	Polychip & Syngene	Dilution: 340,300 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected
24-10-2012	Syngene	On market purchase	$15,015	1,000,000	1,000,000
23-01-2013	Syngene	On market purchase	$14,127	1,000,000	1,000,000
12-03-2013	Syngene	On market purchase	$22,220	2,000,000	2,000,000
11-07-2013	Syngene	On market sale	$37,125	2,500,000	2,500,000
02-07-2013	Polychip & Syngene	Dilution: 3,000,000 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected
21-11-2013	Polychip & Syngene	Consolidation of shares 1 for 10	N/A	Number of ordinary shares not affected	Number of votes/shares not affected

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Form 604 Section 671B - Corporations Act 2001 Notice of Change of Interests of Substantial Shareholder

19-03-2014	Syngene	On market sale	$9,453	50,000	50,000
20-03-2014	Syngene	On market sale	$945	5,000	5,000
17-01-2014	Polychip & Syngene	Dilution: 1,000 shares issued	N/A	Nil	Nil
21-03-2014	Syngene	On market sale	$8,507	45,000	45,000
24-03-2014	Syngene	On market sale	$39,800	200,000	200,000
09-04-2014	Syngene	On market purchase	$4,824	30,000	30,000
01-10-14	Polychip & Syngene	Dilution: 7,913,043 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected
12-11-2014	Polychip & Syngene	Dilution: 9,478,262 shares issued	N/A	Number of ordinary shares not affected	Number of votes/shares not affected

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