Opthea Ltd — Director's Dealing 2024

Apr 3, 2024

Appendix 3Z Final Director’s Interest Notice

Rule 3.19A.3

Appendix 3Z

Final Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity: Opthea Limited

ABN: 32 006 340 567

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	Dan Spiegelman
Date of last notice	18 November 2022
Date that director ceased to be director	04 April 2024

Part 1 – Director’s relevant interests in securities of which the director is the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

• 2,000,000 unquoted options to purchase shares at an exercise price of $2.990 expiring on 12 October 2024 granted under the NED plan.

• 2,000,000 unquoted options to purchase shares at an exercise price of $0.9950 expiring on 16 November 2032 granted under the NED plan.

150,000 unquoted performance rights to purchase share at Nil exercise price expiring on 16 November 2032, granted under the NED plan.

• See chapter 19 for defined terms.

11/3/2002

Appendix 3Z Page 1

Appendix 3Z Final Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interest	Number & class of securities
Note: Provide details of the circumstances giving rise
to the relevant interest

Part 3 – Director’s interests in contracts

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder	N/A
(if issued securities)
No. and class of securities to which	N/A
interest relates

• See chapter 19 for defined terms.

Appendix 3Z Page 2

11/3/2002