Opthea Ltd — Director's Dealing 2023

Jun 8, 2023

Appendix 3Z Final Director’s Interest Notice

Rule 3.19A.3

Appendix 3Z

Final Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity: Opthea Limited

ABN: 32 006 340 567

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	Michael Sistenich
Date of last notice	29 November 2022
Date that director ceased to be director	7 June 2023

Part 1 – Director’s relevant interests in securities of which the director is the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

1,411,048 ordinary shares fully paid

• 1,500,000 unquoted options to purchase shares at an exercise price of $0.975112 expiring on 16 November 2032 granted under the NED plan.

• See chapter 19 for defined terms.

11/3/2002

Appendix 3Z Page 1

Appendix 3Z Final Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of holder & nature of interest Number & class of securities Note: Provide details of the circumstances giving rise to the relevant interest BNP Paribas Nominees Pty Ltd (IB 520,178 ordinary shares fully paid AU NOMS RETAILCLIENT DRP): Michael Sistenich is closely related to the beneficiary of the account Gachis Advisory Pty Ltd : Michael 890,870 ordinary shares fully paid Sistenich is closely related to the beneficiary of the account

Part 3 – Director’s interests in contracts

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder(if issued securities)	N/A
No. and class of securities to whichinterest relates	N/A

• See chapter 19 for defined terms.

Appendix 3Z Page 2

11/3/2002