Opthea Ltd — Director's Dealing 2014

Nov 18, 2014

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/09/01 Amended 01/01/11

Name of entity Circadian Technologies Limited

ABN 32 006 340 567

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Tina Renna McMeckan
Date of last notice	20 May 2013

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Indirect interest
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.	McMeckan Family Superannuation Pty LtdTina McMeckan is a beneficiary of this fund.
Date of change	12 November 2014
No. of securities held prior to change	McMeckan Family Superannuation Pty Ltd- 70,000 ordinary shares, fully paidMcMeckan Investments Pty Ltd-30,000 ordinaryshares,fully paid
Class	Ordinary shares fully paid and listedoptions
Number acquired	40,000 Ordinary shares, fully paid20,000 Listed options, exercise price$0.27, expiry 25 November 2018
Number disposed	Nil
Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	$7,000.00

• See chapter 19 for defined terms.

01/01/2011 Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change	McMeckan Family Superannuation
	Pty Ltd- 98,000 ordinary shares, fully
	paid, 14,000 listed options, exercise price
	$0.27, expiry 25 November 2018.
	McMeckan Investments Pty Ltd-
	42,000 ordinary shares, fully paid, 6,000
	listed options, exercise price $0.27, expiry
	25 November 2018.
Nature of change	Ordinary shares and accompanying listed
Example: on-market trade, off-market trade, exercise of options,issue of securities under dividend reinvestment plan, participation inbuy-back	options acquired pursuant toparticipation in non-renounceable 2 for 5
	rights issue announced on 6 October 2014

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	N/A
Nature of interest	N/A
Name of registered holder	N/A
(if issued securities)
Date of change	N/A
No. and class of securities to which	N/A
interest related prior to change
Note: Details are only required for a contract in
relation to which the interest has changed
Interest acquired	N/A
Interest disposed	N/A
Value/Consideration	N/A
Note: If consideration is non-cash, provide details
and an estimated valuation
Interest after change	N/A

Part 3 –[+] Closed period

Were the interests in the securities or contracts detailed No above traded during a[+] closed period where prior written clearance was required? If so, was prior written clearance provided to allow the trade N/A to proceed during this period? If prior written clearance was provided, on what date was this N/A provided?

• See chapter 19 for defined terms.

Appendix 3Y Page 2

01/01/2011