Opthea Ltd — Director's Dealing 2010

May 10, 2010

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity CIRCADIAN TECHNOLOGIES LIMITED ABN 32 006 340 567

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	ROBERT KLUPACS
Date of last notice	9 SEPTEMBER 2009

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	DIRECT INTEREST
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving riseto the relevant interest.	N/A
Date of change	10 MAY 2010

• See chapter 19 for defined terms.

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Appendix 3Y Change of Director’s Interest Notice

No. of securities held prior to change	DIRECT INTEREST – 110,481 ORDINARY SHARES500,000 EMPLOYEE OPTIONS (UNLISTEDSECURITIES)EXERCISE PRICE: $1.50FIRST EXERCISE DATE: 8/2/2011 (subject to share priceperformance hurdles being met)EXPIRY DATE: 8/2/2012(CIRAQ)500,000 EMPLOYEE OPTIONS (UNLISTEDSECURITIES)EXERCISE PRICE: $1.30FIRST EXERCISE DATE: 8/2/2011 (subject to share priceperformance hurdles being met)EXPIRY DATE: 8/2/2012(CIRAU)
Class	ORDINARY SHARES
Number acquired	8,133 ORDINARY SHARES
Number disposed	NIL
Value/ConsiderationNote: If consideration is non-cash, provide detailsand estimated valuation	TOTAL CONSIDERATION - $6,017.10
No. of securities held after change	DIRECT INTEREST – 118,614 ORDINARY SHARES500,000 EMPLOYEE OPTIONS (UNLISTEDSECURITIES)EXERCISE PRICE: $1.50FIRST EXERCISE DATE: 8/2/2011 (subject to share priceperformance hurdles being met)EXPIRY DATE: 8/2/2012(CIRAQ)500,000 EMPLOYEE OPTIONS (UNLISTEDSECURITIES)EXERCISE PRICE: $1.30FIRST EXERCISE DATE: 8/2/2011 (subject to share priceperformance hurdles being met)EXPIRY DATE: 8/2/2012(CIRAU)
Nature of changeExample: on-market trade, off-market trade, exerciseof options, issue of securities under dividendreinvestment plan, participation in buy-back	ON-MARKET TRADE

• See chapter 19 for defined terms.

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Appendix 3Y Change of Director’s Interest Notice

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

Detail of contract	-
Nature of interest	-
Name of registered holder(if issued securities)	-
Date of change	-
No. and class of securities to whichinterest related prior to changeNote: Details are only required for a contract in relationto which the interest has changed	-
Interest acquired	-
Interest disposed	-
Value/ConsiderationNote: If consideration is non-cash, provide details andan estimated valuation	-
Interest after change	-

• See chapter 19 for defined terms.

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