Opthea Ltd — Director's Dealing 2007

Oct 24, 2007

Appendix 3Z Final Director’s Interest Notice

Rule 3.19A.3

Appendix 3Z

Final Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity CIRCADIAN TECHNOLOGIES LIMITED ABN 32 006 340 567

We (the entity) give ASX the following information under listing rule 3.19A.3 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of director	GRAEME ROY KAUFMAN
Date of last notice	9 NOVEMBER 2005
Date that director ceased to be director	25 OCTOBER 2007

Part 1 – Director’s relevant interests in securities of which the director is the registered holder

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Number & class of securities

DIRECT INTEREST – 28,500 ORDINARY SHARES

• See chapter 19 for defined terms.

11/3/2002

Appendix 3Z Page 1

Appendix 3Z Final Director’s Interest Notice

Part 2 – Director’s relevant interests in securities of which the director is not the registered holder

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Name of ho	Name of ho	Name of ho
		Name of ho	lder & nature of interes	t	Number & class of	securities
		Note: Provide details of the circumstances giving rise tothe relevant interestNot applicable			NIL

Part 3 – Director’s interests in contracts

	Detail of contract	Detail of contract	NIL	NIL	NIL
	Nature of interest		NIL
	Name of registered holder(if issued securities)		NIL
	No. and class of securities towhich interest relates		NIL

• See chapter 19 for defined terms.

Appendix 3Z Page 2

11/3/2002