Opthea Ltd — Capital/Financing Update 2012

Jun 5, 2012

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6 June 2012

James Gerraty The Companies Section The Australian Stock Exchange Limited Level 4 North Tower, Rialto 525 Collins Street Melbourne, VIC 3000

Dear James

Circadian Technologies Limited (ASX: CIR) – Request for suspension

In reference to our request for trading halt on 5 June 2012, I wish to advise that the company is still in discussions regarding its capital raising and at this time, due to dealing with international investors, those discussions will not be completed prior to the expiry of our trading halt.

Accordingly, pursuant to Listing Rule 17.2, Circadian Technologies Limited ( CIR ) requests that all Circadian shares quoted on the ASX be suspended from trading on the ASX from the commencement of trading on 7 June 2012.

It is expected that the suspension will last until the matters involving the capital raising are completed over the next 2 days, at which time CIR will request the suspension to be lifted.

In accordance with Listing Rule 17.2, CIR provides the following information:

1. Reason for suspension – The suspension is necessary as otherwise trading in CIR shares may take place in an uninformed market and to allow the capital raising to take place in an orderly fashion.

2. Duration of the suspension – CIR expects to make an announcement to the market regarding details of its capital raising before the commencement of trading on 12 June 2012.

3. Termination of suspension – CIR anticipates the suspension will cease upon the earlier of:

   • (a) an announcement by CIR to the market regarding details of its capital raising; and

   • (b) commencement of normal trading on 12 June 2012.

4. No reason – CIR is not aware of any reason why the suspension should not be granted.

5. Further information – none.

Yours faithfully

Susan Madden Company Secretary

Level 1 10 Wallace Avenue Toorak Victoria 3142 Australia T +61 (3) 9826 0399 F +61 (3) 9824 0083 www.circadian.com.au

ABN 32 006 340 567