Opthea Ltd — Capital/Financing Update 2008

Aug 13, 2008

14 August 2008

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Notice under section 708A(5)(e) of the Corporations Act 2001 (Cth)

Issuer: Circadian Technologies Limited ACN 006 340 567

Details of the issue or offer of securities

Class of securities	Ordinary Shares
ASX Code of the securities	CIR
Date of the issue of the securities	14 August 2008
Total number of securities issued	5,117,430 Ordinary Shares

Notice

1. Circadian Technologies Limited gives ASX (as the relevant market operator) notice relating to the issue of securities identified above.

2. This notice is given under paragraph 5(e) of section 708A of the Corporations Act 2001 (Cth).

3. Circadian Technologies Limited issued the securities identified above without disclosure to investors under Part 6D.2 of the Corporations Act 2001 (Cth).

4. As at the date of this notice, Circadian Technologies Limited has complied with:

   • (a) the provisions of Chapter 2M of the Corporations Act 2001 (Cth) as they apply to it; and

   • (b) section 674 of the Corporations Act 2001 (Cth).

5. There is no excluded information (as defined in section 708A(7) of the Corporations Act 2001 (Cth)) as at the date of this notice.

Signed for and on behalf of the Issuer:

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Name: Natalie Korchev Position held: Company Secretary

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Level 1, 10 Wallace Avenue, Toorak, Victoria 3142, Australia P: +61 (3) 9826 0399 F: +61 (3) 9824 0083 www.circadian.com.au

Circadian Technologies Limited ABN 32 006 340 567