OPKO Health Inc.

Registration Form • Sep 23, 2017

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OPKO HEALTH, INC
Corporation no: 2279206	10802
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	Israel Securities Authority			Tel Aviv Stock Exchange		C002 ( Public )		Reported via MAGNA:	23/09/2017
	www.isa.gov.il			www.tase.co.il				Reference:	2017-02-094344	Time of broadcast: 14:24 14:19:58

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Immediate ReportRegulation 4 of the Securities Regulations, (Periodic and Immediate Reports of Foreign Corporation) 5761-2000

	The corporation is a foreign private issuer as defined by U.S. Securities Laws.

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20170923Frost13DEx1Signed.pdf

References of previous documents relating to this matter(the reference does not constitute incorporation by reference):
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Stock Exchange/Market: NYSE	Date of revision of form structure: 09/08/2017
Address: Golda Meir 7 , Nes Ziona 7414002   Israel , Israel Tel: 08-9300051 , Fax: 08-9300091
E-mail address: yphilip@opko.com   Company site: Www.Opko.Com
Previous names of reporting entity:
Name of the Signatory: Philip Yifat Position of Signatory in the reporting corporation: General Counsel Name of Employer Company:
Address: Golda Meir 7 , Nes Ziona 7414002 Telephone: 08-9300051 Facsimile: 08-9300091 E-mail: yphilip@opko.com 1
Israel