OPKO Health Inc.

Proxy Solicitation & Information Statement • Mar 16, 2025

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant ☒ Filed by a party other than the Registrant ☐

Check the appropriate box:

• ☐ Preliminary Proxy Statement
• ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
• ☐ Definitive Proxy Statement
• ☒ Definitive Additional Materials
• ☐ Soliciting Material under 240.14a-12

OPKO Health, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box)

• ☒ No fee required
• ☐ Fee paid previously with preliminary materials.
• ☐ Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.

Your vote matters!

OPKO Health, Inc. Annual Meeting of Stockholders

Wednesday, April 23, 2025 10:00 AM, Eastern Time

Annual Meeting to be held live via the Internet - please visit www.proxydocs.com/OPK for more details.

You must register to attend the meeting online and/or participate at www.proxydocs.com/OPK

For a convenient way to view proxy materials, VOTE, and obtain directions to attend the meeting go to www.proxydocs.com/OPK

To vote your proxy while visiting this site, you will need the 12 digit control number in the box below.

This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. This is not a ballot. You cannot use this notice to vote your shares. We encourage you to access and review all of the important information contained in the proxy materials before voting.

Under United States Securities and Exchange Commission rules, proxy materials do not have to be delivered in paper. Proxy materials can be distributed by making them available on the internet.

If you want to receive a paper or e-mail copy of the proxy material, you must request one. There is no charge to you for requesting a copy. In order to receive a paper package in time for this year's meeting, you must make this request on or before April 11, 2025.

SEE REVERSE FOR FULL AGENDA

Copyright @ 2025 BetaNXT, Inc. or its affiliates. All Rights Reserved

Meeting Materials: Notice of Meeting and Proxy Statement & Annual Report or Form 10-K

Important Notice Regarding the Availability of Proxy Materials for the Stockholders Meeting To Be Held On April 23, 2025 For Stockholders as of February 24, 2025

To order paper materials, use one of the following methods.

Internet: www.investorelections.com/OPK

1-866-648-8133

Email: paper@investorelections.com

· If requesting material by e-mail, please send a black e-mail with the 12 digit control number (located below) in the subject line. No other
requests, Instructions OR other inquiries should be locluded with your e-mail requesting macerial.

Your control number

Have the 12 digit control number located in the box above available when you access the website and follow the instructions.

OPKO Health, Inc. Annual Meeting of Stockholders

THE BOARD OF DIRECTORS RECOMMENDS A VOTE:

FOR ON PROPOSALS 1, 2 AND 3

		PROPOSAL

1. To elect as directors the eleven nominess named in the attached proxy statement for a ferm of office expiring at the 2026 annual meeting of stockholders or until their respective successors are duly elected and qualified

1.01 Phillip Frost, M.D.

1.02 Jane H. Hsiao, Ph.D., MBA

1.03 Ellas A. Zerhouni, M.D.

1.04 Steven D. Rubin

1.05 Gary J. Nabel, M.D., Ph.D.

1.06 Richard M. Krasno, Ph D

1.07 Prem A. Lachman, M.D.

1.08 Roger J. Medel, M.D.

1.09 John A. Paganelli

1.10 Richard C. Pfenniger, Jr

1.11 Alice Lin-Tsing Yu, M.D., Ph.D.

• 2 To approve a non-binding resolution regarding the compensation paid to the Company's named executive officers
• The ratification of the appointed of Emel & Young LLP as the Corpany's intependent registered public accounting firm for the facal year.
  enting December 31, 2025
• 1. The transaction of such other business as may properly come before the Annual Meeting or any adjournments thereof,