OPKO Health Inc.

Proxy Solicitation & Information Statement • Apr 29, 2019

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

Filed by the Registrant Filed by a party other than the Registrant

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Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material under 240.14a-12

OPKO Health, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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OPKO Health, Inc. is amending its proxy notice & access card filed on Schedule 14A Information with the Securities and Exchange Commission on April 26, 2019 in order to file the correct 2019 notice cards.

	Meeting Information
OPKO HEALTH, INC.	Meeting Type: Annual Meeting
	For holders as of: April 22, 2019
	Date: June 20, 2019 Time: 10:00 a.m., Eastern Time
	Location: Meeting live via the Internet-please visit www.virtualshareholdermeeting.com/OPK2019.
O HEALTH INC. I: KATE INMAN	The company will be hosting the meeting live via the Internet this year. To attend the meeting via the Internet please visit www.virtualshareholdermeeting.com/OPK2019 and be sure to have the information that is printed in the box marked by the arrow -> XXXX XXXX XXXX XXXX (located on the following page). The Company will also be hosting a listen-only conference call. Please note that you will not be able to vote or revoke your proxy via the listen-only conference call.
BISCAYNE BLVD. M. Ft. 33137	You are receiving this communication because you hold shares in the company named above.
	This is not a ballot. You cannot use this notice to vote these shares. This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You may view the proxy materials online at www.proxyvote.com or easily request a paper copy (see reverse side).
	We encourage you to access and review all of the important information contained in the proxy materials before voting,
	See the reverse side of this notice to obtain proxy materials and voting instructions.

Before You Vote

How to Access the Proxy Materials

Proxy Materials Available to VIEW or RECEIVE: NOTICE AND PROXY STATEMENT How to View Online: Have the information that is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> following page) and visit: www.proxyvote.com How to Request and Receive a PAPER or E-MAIL Copy: If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting a copy. Please choose one of the following methods to make your request: I) BY INTERNET: www.proxyvote.com 2) BY TELEPHONE: 1-800-579-1639 3) BY E-MAIL*: sendmaterial@proxyvote.com * If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please make the request as instructed above on or before June 6, 2019 to facilitate timely delivery.

How To Vote

Please Choose One of the Following Voting Methods

Vote By Internet:
Before The Meeting: Go to www.broxywe.com. Have the information that is printed in the box marked by the arrow ->>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> following page) available and follow the instructions.
Dunng The Meeting:
Go to www.virtualshareholdermeeting.com/OPK2019. Have the is printed in the box marked by the arrow -> XXXX XXXX XXXX (located on the following page) available and follow the instructions.
Please note that you will not be able to vote or revole comerence call to take place simulaneously with the webcast of the Annual Meeting.
Vote By Mail: You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.

E72894-P21847

Voting Items THE BOARD OF DIRECTORS PECTORS PECOMMENTS A VOILE TORE
THE PORTONE ANDREACTORS PER COMMENTS CENTERSEAL
ACTING CORPORATIONS THE COMPANY CANALA CARALA AND SEALER
AND TERESTED P

Election of nine directors. 11-

NOMINEES
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(02) 03) 04)	01) Phillip Frost, M.D. Jane H. Hsiao, Ph.D., MBA Steven D. Rubin Robert S. Fishel, M.D.	07) 08)	06) Richard A. Lerner, M.D. John A. Paganelli Richard C. Pfenniger, Jr. 09) Alice Lin-Tsing Yu, M.D., Ph.D.
	05) Richard M. Krasno, Ph.D.

1. To appove an amendment to the Company's amended and restation the "Cetificate of lincoporation 1).

2. A non-binding advisory vote to approve the compensation paid to named executive officers of the Company ("Say on Pay").

3. I lo ratify the appointment of Enst & Young LP as the Company's independent registered public accounting firm for the fiscalyear ending of the fiscalyers ending of the fis

In their discretion, the proxy holders are authorized to vote upon such other matters as may properly come before the meeting or any a
postponement or adjournment thereof. 5.