OPKO Health Inc.

Major Shareholding Notification • Jan 11, 2024

1/10/24, 4:35 PM Ownership Submission

FORM 4
Check this box if no longer subject to Section 16. Form 4 or
Form 5 obligations may continue. See	UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Instruction 1(b). Check this box to indicate that a	Washington, D.C. 20549
transaction was made pursuant to a contract,	STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
instruction or written plan for the purchase or sale of equity securities of the issuer	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
that is intended to satisfy the affirmative defense conditions of
Rule 10b5-1(c). See Instruction 10.

(Print or Type Responses)

1. Name and Address of Reporting Person * Gary J. Nabel, M.D., Ph.D.			2. Issuer Name and Ticker or Trading Symbol OPKO Health, Inc. [ OPK ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director _____ 10% Owner
(Last) OPKO Health, Inc. 4400 Biscayne Blvd.	(First) (Middle) (Street) (State) (Zip)		3. Date of Earliest Transaction (Month/Day/Year) 01/08/2024	__ X __ Officer (give title below) _____ Other (specify below) Chief Innovation Officer
Miami, FL 33137 (City)			4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security	2. Transaction	2A. Deemed	3. Transaction		4. Securities Acquired (A)			5. Amount of Securities	6.	7. Nature
(Instr. 3)	Date	Execution Date, if	Code		or Disposed of (D)			Beneficially Owned Following	Ownership	of Indirect
	(Month/Day/Year)	any	(Instr. 8)		(Instr. 3, 4 and 5)			Reported Transaction(s)	Form:	Beneficial
		(Month/Day/Year)						(Instr. 3 and 4)	Direct (D)	Ownership
						(A)			or Indirect	(Instr. 4)
						or			(I)
			Code	V	Amount	(D)	Price		(Instr. 4)

OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5 1/10/24, 4:35 PM Ownership Submission

Common Stock	01/08/2024	P	108,695	A	\$ 0.925	351,442	I	See Footnote (1)
Common Stock	01/08/2024	P	500	A	\$ 0.9178	500	I	By Spouse (2)
Common Stock	01/08/2024	P	106,989	A	\$ 0.9293	107,489 (2)	I	By Spouse (2)
Common Stock						263,079	D
Common Stock						19,912,459	I	See Footnote (3)
Common Stock						19,912,459	I	See Footnote (4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)

1. Title of	2.	3. Transaction	3A. Deemed	4.		5. Number		6. Date Exercisable		7. Title and		8. Price of	9. Number of	10.	11. Nature
Derivative	Conversion	Date	Execution Date, if	Transaction		of		and Expiration Date		Amount of		Derivative	Derivative	Ownership	of Indirect
Security	or Exercise	(Month/Day/Year)	any	Code		Derivative		(Month/Day/Year)		Underlying		Security	Securities	Form of	Beneficial
(Instr. 3)	Price of		(Month/Day/Year)	(Instr. 8)		Securities				Securities		(Instr. 5)	Beneficially	Derivative	Ownership
	Derivative					Acquired				(Instr. 3 and 4)			Owned	Security:	(Instr. 4)
	Security					(A) or							Following	Direct (D)
						Disposed							Reported	or Indirect
						of (D)							Transaction(s)	(I)
						(Instr. 3, 4,							(Instr. 4)	(Instr. 4)
						and 5)
											Amount
								Date	Expiration		or
								Exercisable	Date	Title	Number
				Code	V	(A)	(D)				of Shares

Explanation of Responses:

1. Shares held by the Nabel Family Investments LLC, of which the Reporting Person is the manager with sole investment power and has an approximately 48% interest through the parent trust, the 2009 Nabel Family Children's Trust of which the Reporting Person has sole control, and sole investment power. The Reporting Per disclaims beneficial ownership

1/10/24, 4:35 PM Ownership Submission

of these securities, except to the extent of any pecuniary interest therein and this report shall not be dee admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

• 2. Shares held by the Elizabeth G. Nabel ROTH Contributory IRA. Excludes 113,200 shares purchased in 2022. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
• 3. Shares held by the GJN 2021 TRUST for the benefit of the Reporting Person's spouse and descendants, and for which the Reporting Person's spouse serves as co-trustee together with an independent trustee. The Reporting Person's spouse and the independent trustee serve as investment advisors of the trust. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
• 4. Shares held by the EGN 2021 TRUST for the benefit of the Reporting Person and his descendants, and for which an independent trustee has been appointed. The Reporting Person and the independent trustee serve as investment advisors of the trust. The Reporting Person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

Signatures

Steven D. Rubin, Attorney-in-Fact 01/10/2024

Signature of Reporting Person Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

• * If the form is filed by more than one reporting person, see Instruction 4(b)(v).
• ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

**

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