OPKO Health Inc.

Major Shareholding Notification • May 10, 2022

FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person OPKO Health, Inc.		2. Date of Event Requiring Statement (Month/Day/Year)	3. Issuer Name and Ticker or Trading Symbol Sema4 Holdings, Corp. [SMFR]
(Last) 4400 Biscayne Blvd.	(First)	(Middle)	04/29/2022	4. Relationship of Reporting Person(s) to 5. If Amendment, Date Original Issuer Filed(Month/Day/Year) (Check all applicable)
(Street) Miami	FL	33137		_ Director 6. Individual or Joint/Group Filing (Check X 10% Owner _ Officer (give title ____ Other (specify Applicable Line) below) below) X Form filed by One Reporting Person
(City)	(State)	(Zip)		____ Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security (Instr. 4)			Owned (Instr. 4)	2. Amount of Securities Beneficially 3. Ownership 4. Nature of Indirect Beneficial Ownership Form: Direct (D) (Instr. 5) or Indirect (I) (Instr. 5)

Class A Common Stock, par value \$0.0001 per share 80,000,000 D

Table II - Derivative Securities Beneficially Owned ( e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative	5. Ownership Form of Derivative	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	Security	Security: Direct (D) or Indirect (I) (Instr. 5)

Explanation of Responses:

/s/Steven D. Rubin, authorized signatory 05/09/2022

**Signature of Reporting Person Date

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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