OPKO Health Inc.

Major Shareholding Notification • Aug 15, 2017

FORM 4

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may

UNITED STATES SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

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STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

continue. See Instruction 1(b).

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OPKO Health, Inc.	1. Name and Address of Reporting Person		2. Issuer Name and Ticker or Trading Symbol Sevion Therapeutics, Inc. [SVON]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) ____ Director
(Last)	(First) (Middle) 4400 Biscayne Blvd.		3. Date of Earliest Transaction (Month/Day/Year) 08/10/2017	X 10% Owner _ Officer (give title below)_ Other (specify below)
(Street) Miami	FL	33137	4. If Amendment, Date Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person ____ Form filed by More than One Reporting Person
(City)	(State)	(Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s)	6. Ownership Form:	7. Nature of Indirect Beneficial
		(Month/Day/Year)	Code	V	Amount	(A) or (D)	Price	(Instr. 3 and 4)	Direct (D) or Indirect (I) (Instr. 4)	Ownership (Instr. 4)
Common Stock	08/10/2017		(1) C		1,563,123	A	\$0.1	12,080,139	D
Common Stock	08/10/2017		(2) C		2,563,699	A	\$0.1	14,643,838	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)	5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)			6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Underlying Securities (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of Derivative Securities Beneficially Owned Following Reported	10. Ownership Form of Derivative Security: Direct (D) or Indirect	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares		Transaction(s) (Instr. 4)	(I) (Instr. 4)
Convertible Promissory (3) Note	\$0.1	08/10/2017		(1) C			\$150,000	11/10/2016	11/10/2017	Common Stock	1,500,000	\$ 0	0	D
Convertible Promissory (3) Note	\$0.1	08/10/2017		(2) C			\$250,000	02/24/2017	08/24/2017	Common Stock	2,500,000	\$ 0	0	D

Explanation of Responses:

(1) Pursuant to the terms of the Convertible Note, the Reporting Person acquired (i) 1,500,000 shares of Common Stock upon conversion of \$150,000 in principal amount of the Convertible Note, and (ii) 63,123 shares of Common Stock in accrued and previously unpaid interest thereon (\$6,312.33).

(2) Pursuant to the terms of the Convertible Note, the Reporting Person acquired (i) 2,500,000 shares of Common Stock upon conversion of \$250,000 in principal amount of the Convertible Note, and (ii) 63,699 shares of Common Stock in accrued and previously unpaid interest thereon (6,369.86).

(3) The derivative security was previously subject to a "blocker" pursuant to which the reporting person was unable to convert the derivative security to the extent such conversion would result in the reporting person owning more than 4.99%.

Adam Logal, Chief Financial Officer 08/14/2017

**Signature of Reporting Person Date

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