OPKO HEALTH, INC. — Director's Dealing 2016

Oct 18, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Opko Health, Inc. (OPK)
CIK: 0000944809
Period of Report: 2016-10-17

Reporting Person: FROST PHILLIP MD ET AL (Director, CEO & Chairman, 10% Owner)
Reporting Person: Frost Gamma Investments Trust (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2016-10-17	Common Stock	P	1800	$9.32	Acquired	160217343	Indirect
2016-10-17	Common Stock	P	100	$9.365	Acquired	160217443	Indirect
2016-10-17	Common Stock	P	1700	$9.37	Acquired	160219143	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	3068951	Direct
Common Stock	20091062	Indirect

Footnotes

F1: The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2: These securities are owned directly by The Frost Group, LLC. Frost Gamma Investments Trust is a principal member of The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.