OPKO HEALTH, INC. — Director's Dealing 2014

Feb 18, 2014

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Opko Health, Inc. (OPK)
CIK: 0000944809
Period of Report: 2014-02-14

Reporting Person: FROST PHILLIP MD ET AL (Director, CEO & Chairman, 10% Owner)
Reporting Person: Frost Gamma Investments Trust (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2014-02-14	Common Stock	P	200	$8.529	Acquired	139197659	Indirect
2014-02-14	Common Stock	P	1500	$8.5299	Acquired	139199159	Indirect
2014-02-14	Common Stock	P	2300	$8.53	Acquired	139201459	Indirect
2014-02-14	Common Stock	P	100	$8.6075	Acquired	139201559	Indirect
2014-02-14	Common Stock	P	100	$8.609	Acquired	139201659	Indirect
2014-02-14	Common Stock	P	1700	$8.61	Acquired	139203359	Indirect
2014-02-14	Common Stock	P	200	$8.6199	Acquired	139203559	Indirect
2014-02-14	Common Stock	P	900	$8.62	Acquired	139204459	Indirect
2014-02-14	Common Stock	P	900	$8.66	Acquired	139205359	Indirect
2014-02-14	Common Stock	P	1300	$8.67	Acquired	139206659	Indirect
2014-02-14	Common Stock	P	3200	$8.68	Acquired	139209859	Indirect
2014-02-14	Common Stock	P	1600	$8.69	Acquired	139211459	Indirect
2014-02-14	Common Stock	P	2400	$8.71	Acquired	139213859	Indirect
2014-02-14	Common Stock	P	2700	$8.72	Acquired	139216559	Indirect
2014-02-14	Common Stock	P	1400	$8.73	Acquired	139217959	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1987500	Direct
Common Stock	15490546	Indirect

Footnotes

F1: The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2: These securities are owned directly by The Frost Group, LLC. Frost Gamma Investments Trust is a principal member of The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.