OPKO HEALTH, INC. — Director's Dealing 2012

Apr 13, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Opko Health, Inc. (OPK)
CIK: 0000944809
Period of Report: 2012-04-12

Reporting Person: FROST PHILLIP MD ET AL (Director, CEO & Chairman, 10% Owner)
Reporting Person: Frost Gamma Investments Trust (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-04-12	Common Stock	P	10000	$4.43	Acquired	110795854	Indirect
2012-04-12	Common Stock	P	200	$4.455	Acquired	110796054	Indirect
2012-04-12	Common Stock	P	14080	$4.4601	Acquired	110810134	Indirect
2012-04-12	Common Stock	P	6200	$4.471	Acquired	110816334	Indirect
2012-04-12	Common Stock	P	8460	$4.4803	Acquired	110824794	Indirect
2012-04-12	Common Stock	P	4460	$4.4907	Acquired	110829254	Indirect
2012-04-12	Common Stock	P	12460	$4.50	Acquired	110841714	Indirect
2012-04-12	Common Stock	P	14840	$4.51	Acquired	110856554	Indirect
2012-04-12	Common Stock	P	4532	$4.52	Acquired	110861086	Indirect
2012-04-12	Common Stock	P	3500	$4.53	Acquired	110864586	Indirect
2012-04-12	Common Stock	P	100	$4.5499	Acquired	110864686	Indirect
2012-04-12	Common Stock	P	5750	$4.5509	Acquired	110870436	Indirect
2012-04-12	Common Stock	P	6753	$4.56	Acquired	110877189	Indirect
2012-04-12	Common Stock	P	368	$4.57	Acquired	110877557	Indirect
2012-04-12	Common Stock	P	1900	$4.5846	Acquired	110879457	Indirect
2012-04-12	Common Stock	P	6397	$4.59	Acquired	110885854	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	15490546	Indirect

Footnotes

F1: The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2: These securities are owned directly by The Frost Group, LLC. Frost Gamma Investments Trust is a principal member of The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.