OPKO HEALTH, INC. — Director's Dealing 2012

Nov 1, 2012

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Opko Health, Inc. (OPK)
CIK: 0000944809
Period of Report: 2012-10-31

Reporting Person: FROST PHILLIP MD ET AL (Director, CEO & Chairman, 10% Owner)
Reporting Person: Frost Gamma Investments Trust (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-10-31	Common Stock	P	3460	$4.23	Acquired	118174214	Indirect
2012-10-31	Common Stock	P	6300	$4.24	Acquired	118180514	Indirect
2012-10-31	Common Stock	P	3549	$4.2545	Acquired	118184063	Indirect
2012-10-31	Common Stock	P	8200	$4.26	Acquired	118192263	Indirect
2012-10-31	Common Stock	P	13491	$4.27	Acquired	118205754	Indirect
2012-10-31	Common Stock	P	15000	$4.28	Acquired	118220754	Indirect
2012-10-31	Common Stock	P	1000	$4.29	Acquired	118221754	Indirect
2012-10-31	Common Stock	P	13400	$4.30	Acquired	118235154	Indirect
2012-10-31	Common Stock	P	3900	$4.32	Acquired	118239054	Indirect
2012-10-31	Common Stock	P	6700	$4.33	Acquired	118245754	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	15490546	Indirect

Footnotes

F1: The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2: These securities are owned directly by The Frost Group, LLC. Frost Gamma Investments Trust is a principal member of The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.