OPKO HEALTH, INC. — Director's Dealing 2010

May 14, 2010

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Opko Health, Inc. (OPK)
CIK: 0000944809
Period of Report: 2010-05-13

Reporting Person: FROST PHILLIP MD ET AL (Director, CEO & Chairman, 10% Owner)
Reporting Person: Frost Gamma Investments Trust (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2010-05-13	Common Stock	P	2500	$2.12	Acquired	97467552	Indirect
2010-05-13	Common Stock	P	1644	$2.14	Acquired	97469196	Indirect
2010-05-13	Common Stock	P	3300	$2.15	Acquired	97472496	Indirect
2010-05-13	Common Stock	P	56	$2.16	Acquired	97472552	Indirect

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	15490546	Indirect

Footnotes

F1: The securities are held by Frost Gamma Investments Trust, of which Phillip Frost M.D., is the trustee. Frost Gamma L.P. is the sole and exclusive beneficiary of Frost Gamma Investments Trust. Dr. Frost is one of two limited partners of Frost Gamma L.P. The general partner of Frost Gamma L.P. is Frost Gamma, Inc., and the sole shareholder of Frost Gamma, Inc. is Frost-Nevada Corporation. Dr. Frost is also the sole shareholder of Frost-Nevada Corporation. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.

F2: These securities are owned directly by The Frost Group, LLC. Frost Gamma Investments Trust is a principal member of The Frost Group, LLC. The reporting person disclaims beneficial ownership of these securities, except to the extent of any pecuniary interest therein and this report shall not be deemed an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.