OnKure Therapeutics, Inc. — Director's Dealing 2021

Apr 8, 2021

SEC Form 3 — Initial Statement of Beneficial Ownership

Issuer: Reneo Pharmaceuticals, Inc. (RPHM)
CIK: 0001637715
Period of Report: 2021-04-08

Reporting Person: RiverVest Venture Fund III, L.P. (10% Owner)
Reporting Person: RiverVest Venture Fund III (Ohio), L.P. (10% Owner)
Reporting Person: RiverVest Venture Fund IV, L.P. (10% Owner)

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	279342	Indirect

Holdings (Derivative)

Security	Exercise Price	Expiration	Underlying	Shares	Ownership
Series A Preferred Stock	$		Common Stock (1100765)		Indirect
Series B Preferred Stock	$		Common Stock (829113)		Indirect

Footnotes

F1: RiverVest Venture Fund III, L.P. ("RiverVest III") owns 265,263 shares of Common Stock. RiverVest Venture Fund III (Ohio), L.P. ("RiverVest (Ohio) III") owns 14,079 shares of Common Stock.

F2: Each share of Series A Preferred Stock and Series B Preferred Stock has no expiration date and are convertible at any time at the election of the holder without payment of further consideration. Each share of Series A Preferred Stock and Series B Preferred Stock will automatically convert into 1 share of Common Stock for each 4.4748 shares of Preferred Stock based upon the conversion price currently in effect. Share numbers (including those noted in the footnotes below) give effect to such conversion in connection with the closing of the Issuer's initial public offering.

F3: RiverVest III owns 62,831 shares of Series A Preferred Stock. RiverVest (Ohio) III owns 3,334 shares of Series A Preferred Stock. RiverVest Venture Fund IV, L.P. ("RiverVest IV") owns 1,034,600 shares of Series A Preferred Stock.

F4: The shares held by RiverVest III are indirectly held by RiverVest Venture Partners III, L.P. ("RiverVest Partners III"), which is the general partner of RiverVest III. The shares held by RiverVest (Ohio) III are indirectly held by RiverVest Venture Partners III (Ohio), LLC ("RiverVest Partners (Ohio) III"), which is the general partner of RiverVest (Ohio) III. RiverVest Partners III is the sole member of RiverVest Partners (Ohio) III. RiverVest Venture Partners III, LLC is the general partner of RiverVest Partners III.

F5: The individual managers of RiverVest Ventures Partners III, LLC are Thomas C. Melzer, Jay Schmelter and John P. McKearn, Ph.D. RiverVest Partners III, RiverVest Partners (Ohio) III, RiverVest Venture Partners III, LLC and each of the individual managers share voting and dispositive power with regard to the Issuer's securities directly held by RiverVest Venture Fund III, L.P. and RiverVest Venture Fund III (Ohio), L.P.

F6: RiverVest IV owns 829,113 shares of Series B Preferred Stock.

F7: The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.