OnKure Therapeutics, Inc. — Director's Dealing 2021

Apr 13, 2021

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: Reneo Pharmaceuticals, Inc. (RPHM)
CIK: 0001637715
Period of Report: 2021-04-09

Reporting Person: RiverVest Venture Fund III, L.P. (10% Owner)
Reporting Person: RiverVest Venture Fund III (Ohio), L.P. (10% Owner)
Reporting Person: RiverVest Venture Fund IV, L.P. (10% Owner)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2021-04-09	Common Stock	C	1100765	—	Acquired	1380107	Indirect
2021-04-09	Common Stock	C	829113	—	Acquired	2209220	Indirect
2021-04-09	Common Stock	P	200000	$15.00	Acquired	2409220	Indirect

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2021-04-09	Series A Preferred Stock	$	C	4925711	Disposed		Common Stock (1100765)	Indirect
2021-04-09	Series B Preferred Stock	$	C	3710116	Disposed		Common Stock (829113)	Indirect

Footnotes

F1: Each share of Series A Preferred Stock and Series B Preferred Stock automatically converted into 1 share of the Issuer's common stock for each 4.4748 shares of Preferred Stock upon the closing of the Issuer's initial public offering on April 9, 2021. The shares have no expiration date.

F2: Consists of shares held of record by (i) RiverVest Venture Fund III, L.P. ("RiverVest III"), (ii) RiverVest Venture Fund III (Ohio), L.P. ("RiverVest (Ohio) III"), and (iii) RiverVest Venture Fund IV, L.P ("RiverVest IV").

F3: The shares held by RiverVest III are indirectly held by RiverVest Venture Partners III, L.P. ("RiverVest Partners III"), which is the general partner of RiverVest III. The shares held by RiverVest (Ohio) III are indirectly held by RiverVest Venture Partners III (Ohio), LLC ("RiverVest Partners (Ohio) III"), which is the general partner of RiverVest (Ohio) III. RiverVest Partners III is the sole member of RiverVest Partners (Ohio) III. RiverVest Venture Partners III, LLC is the general partner of RiverVest Partners III.

F4: The individual managers of RiverVest Ventures Partners III, LLC are Thomas C. Melzer, Jay Schmelter and John P. McKearn, Ph.D. RiverVest Partners III, RiverVest Partners (Ohio) III, RiverVest Venture Partners III, LLC and each of the individual managers share voting and dispositive power with regard to the Issuer's securities directly held by RiverVest Venture Fund III, L.P. and RiverVest Venture Fund III (Ohio), L.P.

F5: Consists of shares held of record by RiverVest IV.

F6: The shares held by RiverVest IV are indirectly held by RiverVest Venture Partners IV, L.P., its general partner ("RiverVest Partners IV"). RiverVest Venture Partners IV, LLC is the general partner of RiverVest Partners IV. The individual managers of RiverVest Ventures Partners IV, LLC are Jay Schmelter, John P. McKearn, Ph.D. and Niall O'Donnell, a member of the Issuer's board of directors. RiverVest Partners IV, RiverVest Venture Partners IV, LLC and each of the individual managers share voting and dispositive power with regard to the Company's securities directly held by RiverVest IV.

F7: RiverVest IV purchased the shares in the Issuer's initial public offering.

F8: The 2,409,220 shares consists of (i) 328,094 shares held of record by RiverVest III, (ii) 17,413 shares held of record by RiverVest (Ohio) III, and (iii) 2,063,713 shares held of record by RiverVest IV.