Regulatory Filings • Sep 22, 2010
Regulatory Filings
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Highly ranked Journal of Alzheimer's Disease to publish two DiaGenic
ADtect® articles
Abstracts of two articles to be published in the highly ranked Journal
of Alzheimer's Disease have been posted today on the journal's web site.
This will build confidence in ADtect® among clinicians and
pharmaceutical companies and confirm DiaGenic's leading position as a
provider of biomarkers in the CNS field.
The article "A Gene Expression Pattern in Blood for the Early Detection
of Alzheimer's Disease" discusses the identification and validation of a
gene expression signature in blood that classifies AD patients and
cognitively healthy controls with high accuracy. The study is based on a
Whole Genome Study in Alzheimer patients and healthy controls. The
article shows that Alzheimer's disease can be detected distant from the
site of the disease with the aid of gene expression.
The second article "A Novel Blood Test for the Early Detection of
Alzheimer's Disease" discusses the CE studies on ADtect® and the results
from extensive validations of ADtect®. The study provides documentation
of the robustness of ADtect® and discusses the accuracy of the test.
Assuming a clinical accuracy of 80%, statistical modelling indicates
that the agreement with underlying true pathology is in the range
85%-90%. 32 genes of the 96 gene signature of the test are associated
with known AD pathology and supports that ADtect measures changes
related to the disease. These findings support that the gene expression
blood test can aid in the diagnosis of mild to moderate AD.
"Journal of Alzheimer's Disease is the most prolific and highly cited
journal in the Alzheimer's disease field. Therefore we are extremely
satisfied having two articles accepted by the journal discussing
ADtect®. This will build confidence among clinicians and pharma
companies and confirms our position as a leading provider of blood based
gene expression biomarkers in the CNS field", says Erik Christensen MD
PhD, CEO of DiaGenic.
The abstract of the articles can be found at:
http://www.j-alz.com/issues/23/vol23-1.html (http://www.j-alz.com/issues
/23/vol23-1.html) . Once published, both articles will be available at
DiaGenic's web site: www.diagenic.com (http://www.diagenic.com/).
Contact:
Erik Christensen, CEO
Telephone: 47 95939918
e-mail: [email protected]
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