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MorphoSys AG — Investor Presentation 2012
Jan 16, 2012
291_ip_2012-01-16_d2947233-2d34-48e9-a5c0-531287187446.pdf
Investor Presentation
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30th Annual J.P. Morgan Healthcare Conference
January 12, 2012
This presentation includes forward-looking statements.
Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.
These and other risks and uncertainties are detailed in the Company's Annual Report.
MorphoSys – Investment Proposition
Broad Pipeline
78 drug programs – 20 in clinical trials
Proven Technology
Industry's most successful antibody library technology
Increasing Market Penetration Novel diagnostic products
Financial Strength Profitable, strong balance sheet
Experienced Management Team More than 80 years of pharma & biotech experience
Maturing Pipeline Illustrates Successful Execution of Strategy
- 20 clinical programs ongoing
- 16 with seven different partners
- 4 proprietary, un-partnered programs
- Disease areas include cancer, inflammation, CNS, ophthalmology, musculoskeletal, and others
Proven Technology Platform for Making Human Therapeutic Antibodies
Ylanthia – Novel Technology For Unearthing New Antibody Drugs
Full "interrogation" of target is essential for Slonomics inside & for optimization identifying new therapeutic approaches
- New antibody platform comprising over 100 billion fully human antibodies
- Unprecedented structural diversity provides:
- New antibodies against previously inaccessible targets
- Unique epitope coverage
- Improved biophysical properties enhance:
- Production
- Administration
- Stability
78 Therapeutic Antibody Programs Ongoing, 20 in Clinical Trials
| Program | Partner | Indication | Discovery | Pre-clinic | Phase 1 | Phase 2 |
|---|---|---|---|---|---|---|
| MOR103 (2 programs) | - | Rheumatoid arthritis, Multiple sclerosis |
||||
| not discl. | Novartis | not discl. | ||||
| CNTO888 (2 programs) | Centocor/J&J | Cancer, Idiopathic pulmonary fibrosis |
||||
| Gantenerumab | Roche | Alzheimer's Disease | ||||
| BHQ880 | Novartis | Cancer | ||||
| BYM338 | Novartis | Musculoskeletal | ||||
| CNTO 1959 | Centocor/J&J | Psoriasis | ||||
| MOR208 | - | Cancer | ||||
| MOR202 | - | Cancer | ||||
| CNTO 3157 | Centocor/J&J | Asthma | ||||
| not discl. | Centocor/J&J | Inflammation | ||||
| not discl. | Novartis | Ophthalmology | ||||
| not discl. | Novartis | Inflammation | ||||
| not discl. | Boehringer Ingelheim | not discl. | ||||
| not discl. | Pfizer | Cancer | ||||
| OMP-59R5 | Oncomed | Cancer | ||||
| OMP-18R5 | Oncomed | Cancer | ||||
| BAY94-9343 (ADC) | Bayer HealthCare | Cancer | ||||
| 25 Partnered Programs | Various Partners | Various Indications | ||||
| 33 Programs, incl. 2 co-dev with Novartis |
Various Partners | Various Indications | 68 Partnered Programs 10 Proprietary Programs |
Current Pipeline Projected HuCAL Drugs on the Market
Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development
MOR103 Anti-GM-CSF Antibody for Inflammation
- MOR103 is an ultra-high affinity HuCAL antibody against GM-CSF
- GM-CSF is a key inflammatory cytokine
- Activates granulocytes and macrophages
- Stimulates release of other pro-inflammatory mediators
- Triggers release of tissue-degrading substances
- Over-looked target: redundant role in hematopoiesis
-
Pathway clinically validated in rheumatoid arthritis
-
Phase 1b/2a trial in rheumatoid arthritis patients ongoing
- Phase 1b trial in multiple sclerosis patients ongoing
- PK study for sc administration to start in Q1 2012
- Exclusive license to a US patent covering antibodies against GM-CSF for the treatment of chronic inflammatory conditions
2012 Complete enrollment in RA study Results available from RA study Start PK study for sc administration Start enrollment for MS study
MOR208
Anti-Cancer Antibody for B Cell Malignancies
- Humanized antibody against CD19
- In-licensed from Xencor
- Comprises proprietary modification leading to rapid and sustained target cell depletion
- In clinical development for CLL
- Additional trials in other B cell malignancies planned
MOR202 Anti-Cancer Antibody for Multiple Myeloma
- HuCAL antibody against CD38
- Compelling pre-clinical combination data released at ASCO 2011
- MOR202 monotherapy shows dose-dependent reduction of MM graft-induced bone lysis
- MOR202 plus bortezomib or lenalidomide synergistically inhibits bone lysis and substantially reduces M protein levels
- Ongoing phase 1/2a trial:
- Phase 1 dose escalation
- Phase 2a monotherapy extension
- Phase 1b MOR202 plus bortezomib
- Phase 1b MOR202 plus lenalidomide
Partnered Programs Phase 2 Clinical Development
| Program | Partner | Disease | Target | Status |
|---|---|---|---|---|
| n.d. | Novartis | n.d. | n.d. | Clinical proof of concept achieved |
| CNTO888 | Janssen Biotech |
Oncology | CCL2 (MCP-1) |
Two trials ongoing, one trial completed |
| CNTO888 | Janssen Biotech |
Idiopathic pulmonary fibrosis |
CCL2 (MCP-1) |
Novel approach to IPF |
| Gantenerumab | Roche | Alzheimer's disease |
Amyloid-b | Only anti-Aβ being developed in patients with prodromal AD |
| BHQ880 | Novartis | Osteolytic bone disease |
DKK-1 | Early data show stimulation of bone formation |
| BYM338 | Novartis | Musculoskeletal | n.d. | Two phase 2 trials ongoing |
| CNTO1959 | Janssen Biotech |
Psoriasis | n.d. | Phase 2 trial started in December 2011 |
AbD Serotec Segment Complements Therapeutic Business
Antibodies for research and diagnostic markets
Diagnostic Antibodies
- Using proprietary technologies to deliver superior Dx antibodies
- Future upside via royalties
Research Antibodies
- Catalogue of 15,000+ products & custom HuCAL antibodies
- Stable and recurring cash flows
| EUR millions | Guidance 2011 | 2010 |
|---|---|---|
| AbD Serotec Segment Revenues | ~20 | 20.2 |
| AbD Serotec Profit Margin | ~ 4% | 6% |
P&L and Guidance 2011
| EUR millions | 2010 | Guidance 2011 | 9M 2011 |
|---|---|---|---|
| Revenues | 87.0 | slightly below 105 | 83.7 |
| Total Operating Expenses | 77.4 | 64.1 | |
| Proprietary R&D Expenses | 26.3 | 26.1 | |
| Other Operating Income | 0.2 | 0.3 | |
| Profit from Operations | 9.8 | 10 – 13 |
19.9 |
| Balance Sheet | Shareholdings by Investor Type | ||
|---|---|---|---|
| EUR millions | Sep. 30, 2011 |
Dec. 31, 2010 |
Treasury Stock |
| Assets | 0.4% Unidentified |
||
| Cash, Cash Equivalents & Marketable Securities |
143.0 | 108.4 | Management & 17% Supervisory Board |
| Other Current Assets | 20.0 | 24.2 | 2% Novartis |
| Total Non-Current Assets | 76.7 | 80.0 | Institutional 6.4% 46% |
| Total Assets | 239.7 | 212.6 | |
| Liabilities | Retail | ||
| Total Current Liabilities | 29.4 | 21.4 | 28% |
| Total Non-Current Liabilities | 10.1 | 5.3 | |
| Total Shareholders' Equity | 200.2 | 185.9 | |
| Total Liabilities | 239.7 | 212.6 | Shares issued: 23,112,167 (Dec. 31, 2011) |
Management Team
Dr. Simon E. Moroney, CEO
- Co-founder, previously at ImmunoGen
- German Cross of the Order of Merit (2002), Bavarian State Medal for Outstanding Services to the Bavarian Economy (2009)
Jens Holstein, CFO
- Joined MorphoSys in 2011
- Formerly at Fresenius: Regional CFO for region EME of Fresenius Kabi AG; several financial and general management positions at Fresenius; and in consulting industry
Dr. Arndt Schottelius, CDO
- Joined MorphoSys in 2008
- Formerly Medical Director in Immunology at Genentech Inc.; Berlex Biosciences, USA; Schering, Germany; Charité University Hospital, Berlin
Dr. Marlies Sproll, CSO
- Joined MorphoSys in 2000, promoted to CSO in 2005
- Formerly at Boehringer Ingelheim in Vienna; Merck KGaA in Darmstadt
The Pipeline What's Coming Up?
Expected dates for completion of clinical trials (MorphoSys estimates)
Thank You
www.morphosys.com
Dr. Simon Moroney
Chief Executive Officer
Phone +49 (0)89 / 899 27-311 Fax +49 (0)89 / 899 27-5311 Dr. Claudia Gutjahr-Löser Head of Corporate Communications & IR
Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]