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MorphoSys AG — Investor Presentation 2011
May 3, 2011
291_ip_2011-05-03_95678efb-b8af-4768-9faf-5a8a76b56bc1.pdf
Investor Presentation
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Deutsche Bank 36th Annual Health Care Conference
Boston – May 3, 2011
This presentation includes forward-looking statements.
Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.
These and other risks and uncertainties are detailed in the Company's Annual Report.
MorphoSys at a Glance
Financial
Industry's most successful antibody library technology - HuCAL
74 drug programs ongoing
Profitable, strong balance sheet
Page 3
Use proprietary technologies to develop the broadest possible pipeline of therapeutic antibody drugs,
balanced between partnered and proprietary programs
Growing Pipeline Illustrates Successful Execution of Strategy
Clinical Total
Unique & Proprietary Technology for Generating Drug-Quality Antibodies
74 Therapeutic Antibody Programs Ongoing
Current Pipeline Projected HuCAL Drugs on the Market
Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development
The Target
GM-CSF – a growth factor and inflammatory mediator
The Drug
Ultra-high affinity HuCAL IgG1
Clinical Development in Rheumatoid Arthritis
- Phase 1b/2a trial ongoing in Europe in patients with active RA
- Completion of enrollment H2 2011, final results H1 2012
Clinical Development in Multiple Sclerosis
Phase 1b safety study in MS patients starting H2 2011
Intellectual Property
- Exclusive license to a US patent covering antibodies against GM-CSF for the treatment of chronic inflammatory conditions
- US patent on MOR103 composition of matter
Page 9
MOR208 A Novel Anti-Cancer Antibody
The Target
CD19 – a pan B-cell marker
The Drug
- Humanized, high affinity anti-CD19 antibody
- Exclusive license from Xencor
- Comprises a proprietary Xencor modification that leads to rapid and sustained B-cell depletion
Clinical Development in Chronic Lymphocytic Leukemia
- Multi-centre, open-label, multi-dose, single-arm phase 1, dose-escalation study in USA
- Patients with chronic lymphocytic leukemia, who have not responded to or have become refractory to previous therapies
- Xencor funds phase 1 trial from \$13m up-front payment
- Final data expected in 2012
MOR202 A Novel Antibody for Multiple Myeloma
The Target
CD38 – a protein on multiple myeloma cells
The Drug
- High affinity HuCAL antibody
- Excellent cross-reactivity to non-human primate (tox)
Clinical Development in Multiple Myeloma
- Start multi-centre, open-label, dose-escalation study in Europe H1 2011
- Patients with relapsed/refractory multiple myeloma; failure of at least 2 prior therapies
- Maximum tolerated dose, safety and tolerability, pharmacokinetics and immunogenicity; assessment of preliminary activity
- Final data expected in 2013
AbD Serotec Segment Complements Therapeutic Business
Antibodies for research and diagnostic markets
Diagnostic Antibodies
- Using proprietary technologies to deliver superior Dx antibodies
- Future upside via royalties
Research Antibodies
- Catalogue of 15,000+ products & custom HuCAL antibodies
- Stable and recurring cash flows
| EUR millions | Guidance 2011 | 2010 |
|---|---|---|
| AbD Serotec Segment Revenues | 22 - 23 |
20.2 |
| AbD Serotec Profit Margin | ~ 4% | 6% |
P&L and Guidance 2011
| EUR millions | 2010 | Q1 2011 | Guidance 2011 |
|---|---|---|---|
| Revenues | 87.0 | 48.6 | 105 – 110 |
| Total Operating Expenses | 77.4 | 19.9 | |
| Other Operating Income | 0.2 | 0.1 | |
| Profit from Operations | 9.8 | 28.8 | 10 – 13 |
Investment in Proprietary R&D will amount to EUR 40-45 million (2010: EUR 26.3 million)
| Balance Sheet | ||
|---|---|---|
| EUR millions | 31.3.11 | 31.12.10 |
| Assets | ||
| Cash, Cash Equivalents & Marketable Securities |
119.8 | 108.4 |
| Other Current Assets | 47.9 | 24.1 |
| Total Non-Current Assets | 79.0 | 80.0 |
| Total Assets | 246.7 | 212.6 |
| Liabilities | ||
| Total Current Liabilities | 30.3 | 21.4 |
| Total Non-Current Liabilities | 10.6 | 5.3 |
| Total Shareholders' Equity | 205.8 | 185.9 |
| Total Liabilities | 246.7 | 212.6 |
Management Team
Dr. Simon E. Moroney, CEO
- Co-founder; prior positions: University of Cambridge/UK, University of British Columbia/Canada, ETH Zurich/CH, ImmunoGen Inc., Associate in the Harvard Medical School, Boston/USA
- Commonwealth Scholar to the University of Oxford D. Phil. 1984
- German Cross of the Order of Merit (2002), Bavarian State Medal for Outstanding Services to the Bavarian Economy (2009)
Jens Holstein, CFO
- Joined MorphoSys in 2011 from Fresenius Kabi
- Prior positions: Regional CFO for the region EME of Fresenius Kabi AG; variety of financial and general management positions at Fresenius
- Prior to joining Fresenius, Mr. Holstein spent several years in the consulting industry (Frankfurt and London)
- Mr. Holstein holds a Diploma in Business Administration from University of Münster.
Dr. Arndt Schottelius, CDO
- Joined MorphoSys in 2008 from Genentech Inc., SF, position: Medical Director, Immunology Development
- Prior positions: Berlex Biosciences, USA; Schering, Germany; Charité University Hospital, Berlin
- PhD and MD degrees from the Albert-Ludwigs-University, Freiburg/Germany
- Medical studies in Germany, UK and Switzerland
Dr. Marlies Sproll, CSO
- Joined MorphoSys in 2000 as R&D department head, promoted to CSO in 2005
- Prior positions: Vienna research facility of Boehringer Ingelheim, lab leader at Merck KGaA in Darmstadt/ Germany, involved in preclinical development of therapeutic antibodies
- Ph.D. from the Max Planck Institute in Tübingen/Germany, Doctor of Natural Science by the University of Stuttgart
A Rich Potential News-flow in 2011
H1 2011
- US patent granted on MOR103
- Double digit EUR million technology milestone payment received from Novartis
- Release MOR202 pre-clinical data at ASCO
- Commence Phase 1 study of MOR202 in multiple myeloma
- New partner INDs
- Further technology announcements
- First diagnostic kit based on a HuCAL antibody comes to market
H2 2011
- Complete enrollment in MOR103 Phase 1b/2a RA study
- Commence Phase 1b MS study of MOR103
- Clinical data from trial of CNTO888 in oncology*
- Clinical data from trial of CNTO1959 in psoriasis*
- Clinical data from trial of CNTO3157 in asthma*
- New partner INDs
- New deal(s) based on Slonomics technology
* MorphoSys estimates only
Thank You
www.morphosys.com
Dr. Simon Moroney
Chief Executive Officer
Phone +49 (0)89 / 899 27-311 Fax +49 (0)89 / 899 27-5311 Dr. Claudia Gutjahr-Löser Head of Corporate Comm. & IR
Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]
HuCAL®, HuCAL GOLD®, HuCAL PLATINUM®, CysDisplay®, RapMAT® and AutoCAL® are registered trademarks of MorphoSys AG, arYla™ is a trademark of MorphoSys AG