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MorphoSys AG — Investor Presentation 2011
Aug 30, 2011
291_ip_2011-08-30_179947f6-123c-422c-9f1a-f58d2af47298.pdf
Investor Presentation
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Commerzbank Sector Conference
Frankfurt – August 30, 2011
This presentation includes forward-looking statements.
Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.
These and other risks and uncertainties are detailed in the Company's Annual Report.
MorphoSys – Investment Proposition
Broad Pipeline
75 drug programs, 19 in clinical trials
Proven Technology Industry's most successful antibody library technology
Increasing Market Penetration Novel diagnostic products
Financial Strength Profitable, strong balance sheet
Experienced Management Team More than 80 years of pharma & biotech experience
75 Therapeutic Antibody Programs Ongoing, 19 in Clinical Trials
| Program | Partner | Indication | Discovery | Pre-clinic | Phase 1 | Phase 2 |
|---|---|---|---|---|---|---|
| MOR103 (2 programs) | - | Rheumatoid arthritis, Multiple sclerosis |
||||
| not discl. | Novartis | not discl. | ||||
| CNTO888 (2 programs) | Centocor/J&J | Cancer, Idiopathic pulmonary fibrosis |
||||
| Gantenerumab | Roche | Alzheimer's Disease | ||||
| BHQ880 | Novartis | Cancer | ||||
| MOR208 | - | Cancer | ||||
| CNTO 1959 | Centocor/J&J | Psoriasis | ||||
| CNTO 3157 | Centocor/J&J | Asthma | ||||
| not discl. | Centocor/J&J | Inflammation | ||||
| BAY79-4620 | Bayer Schering | Cancer | ||||
| not discl. | Novartis | Musculoskeletal | ||||
| not discl. | Novartis | Ophthalmology | ||||
| not discl. | Novartis | Inflammation | ||||
| not discl. | Boehringer Ingelheim | not discl. | ||||
| not discl. | Pfizer | Cancer | ||||
| OMP-59R5 | Oncomed | Cancer | ||||
| OMP-18R5 | Oncomed | Cancer | ||||
| MOR202 | - | Cancer | ||||
| 21 Partnered Programs | Various Partners | Various Indications | ||||
| 34 Programs, incl. 2 co-dev with Novartis |
Various Partners | Various Indications | 65 Partnered Programs 10 Proprietary Programs |
MOR103 Anti-GM-CSF Antibody for Inflammation
- MOR103 targets inflammatory mediator GM-CSF
- Blocks GM-CSF activity in processes central to inflammation and joint damage associated with rheumatoid arthritis
MOR103 A New, Targeted Anti-Inflammatory Antibody
- HuCAL antibody being developed in major indications
- Phase 1b/2a trial in rheumatoid arthritis patients ongoing
- Phase 1b trial in multiple sclerosis patients planned
- Exclusive license to a US patent covering antibodies against GM-CSF for the treatment of chronic inflammatory conditions
MOR208 A New Anti-Cancer Antibody
MOR202 A New Anti-Cancer Antibody
- HuCAL antibody for multiple myeloma
- Very promising pre-clinical combination data released at ASCO
- Good cross-reactivity to a non-human primate species supports clinical trial design
Page 8
Partnered Programs in Phase 2 Clinical Development
| Program | Partner | Disease | Target | Status |
|---|---|---|---|---|
| n.d. | Novartis | n.d. | n.d. | Clinical proof of concept achieved |
| CNTO888 | Centocor Ortho Biotech |
Oncology | CCL2 (MCP-1) |
Two trials ongoing, one trial completed |
| CNTO888 | Centocor Ortho Biotech |
Idiopathic pulmonary fibrosis |
CCL2 (MCP-1) |
One trial ongoing |
| Gantenerumab | Roche | Alzheimer's disease |
Amyloid-b | Study in patients with prodromal AD |
| BHQ880 | Novartis | Osteolytic bone disease |
DKK-1 | Early data show stimulation of bone formation (three trials ongoing) |
Proven Technology Platform for Making Human Therapeutic Antibodies
HuCAL Human Combinatorial Antibody Library
Modular gene structure
Growing Pipeline Illustrates Successful Execution of Strategy
Clinical Total
Drugs on the Market: Projection from Today's Pipeline
Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development
AbD Serotec Segment Complements Therapeutic Business
Antibodies for research and diagnostic markets
Diagnostic Antibodies
- Using proprietary technologies to deliver superior Dx antibodies
- Future upside via royalties
Research Antibodies
- Catalogue of 15,000+ products & custom HuCAL antibodies
- Stable and recurring cash flows
| EUR millions | Guidance 2011 | 2010 |
|---|---|---|
| AbD Serotec Segment Revenues | 22 - 23 |
20.2 |
| AbD Serotec Profit Margin | ~ 4% | 6% |
P&L and Guidance 2011
| EUR millions | 2010 | Guidance 2011 | H1 2011 |
|---|---|---|---|
| Revenues | 87.0 | 105 – 110 |
66.6 |
| Total Operating Expenses | 77.4 | 43.5 | |
| Proprietary R&D Expenses | 26.3 | 40-45 | 15.2 |
| Other Operating Income | 0.2 | 0.2 | |
| Profit from Operations | 9.8 | 10 – 13 |
23.3 |
| Balance Sheet | ||
|---|---|---|
| EUR millions | June 30, 2011 |
Dec. 31, 2010 |
| Assets | ||
| Cash, Cash Equivalents & Marketable Securities |
139.6 | 108.4 |
| Other Current Assets | 21.3 | 24.1 |
| Total Non-Current Assets | 77.6 | 80.0 |
| Total Assets | 238.6 | 212.6 |
| Liabilities | ||
| Total Current Liabilities | 26.8 | 21.4 |
| Total Non-Current Liabilities | 10.0 | 5.3 |
| Total Shareholders' Equity | 201.8 | 185.9 |
| Total Liabilities | 238.6 | 212.6 |
Page 15
© MorphoSys AG MorphoSys
Shares issued: 23,034,540 (June 30, 2011)
Management Team
Dr. Simon E. Moroney, CEO
- Formerly at ImmunoGen
- German Cross of the Order of Merit (2002), Bavarian State Medal for Outstanding Services to the Bavarian Economy (2009)
Jens Holstein, CFO
- Joined MorphoSys in 2011
- Formerly at Fresenius: Regional CFO for region EME of Fresenius Kabi AG; several financial and general management positions at Fresenius; and in consulting industry
Dr. Arndt Schottelius, CDO
- Joined MorphoSys in 2008
- Formerly Medical Director in Immunology at Genentech Inc.; Berlex Biosciences, USA; Schering, Germany; Charité University Hospital, Berlin
Dr. Marlies Sproll, CSO
- Joined MorphoSys in 2000, promoted to CSO in 2005
- Formerly at Boehringer Ingelheim in Vienna; Merck KGaA in Darmstadt
The Pipeline What's Coming Up?
Dates for completion of clinical trials, see www.clinicaltrials.gov
A Rich Potential News-flow in 2011
Double digit EUR million technology milestone from Novartis
MOR103
- US patent granted on MOR103
- Complete enrollment Phase 1b/2a in rheumatoid arthritis
- Start Phase 1b in multiple sclerosis
- Start clinical study of subcutaneous formulation
- MOR202
- Pre-clinical data presented at ASCO
- Start Phase 1 in multiple myeloma
- Partners
- 1–3 INDs ()
- Data from ongoing studies
First HuCAL antibody-based diagnostic launched
Further technology announcements
Thank You
www.morphosys.com
Dr. Simon Moroney Chief Executive Officer
Phone +49 (0)89 / 899 27-311 Fax +49 (0)89 / 899 27-5311 Jens Holstein Chief Financial Officer
Phone +49 (0)89 / 899 27-439 Fax +49 (0)89 / 899 27-5439 Dr. Claudia Gutjahr-Löser Head of Corporate Comm. & IR
Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]