AI assistant
MorphoSys AG — Investor Presentation 2011
Sep 27, 2011
291_ip_2011-09-27_9331ba95-cb61-4cb5-86fd-3520e8cc1f7a.pdf
Investor Presentation
Open in viewerOpens in your device viewer
Jefferies 2011 Global Healthcare Conference
London – September 27, 2011
This presentation includes forward-looking statements.
Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.
These and other risks and uncertainties are detailed in the Company"s Annual Report.
MorphoSys – Investment Proposition
Broad Pipeline
75 drug programs, 20 in clinical trials
Proven Technology Industry"s most successful antibody library technology
Increasing Market Penetration Novel diagnostic products
Financial Strength Profitable, strong balance sheet
Experienced Management Team More than 80 years of pharma & biotech experience
Growing Pipeline Illustrates Successful Execution of Strategy
Clinical Total
75 Therapeutic Antibody Programs Ongoing, 20 in Clinical Trials
MOR103 Anti-GM-CSF Antibody for Inflammation
- MOR103 targets inflammatory mediator GM-CSF
-
Blocks GM-CSF activity in processes central to inflammation and joint damage associated with rheumatoid arthritis
-
HuCAL antibody being developed in major indications
- Phase 1b/2a trial in rheumatoid arthritis patients ongoing
- Phase 1b trial in multiple sclerosis patients planned
- Exclusive license to a US patent covering antibodies against GM-CSF for the treatment of chronic inflammatory conditions
MOR208 A New Anti-Cancer Antibody
MOR202 A New Anti-Cancer Antibody
- HuCAL antibody for multiple myeloma
- Very promising pre-clinical combination data released at ASCO
- Good cross-reactivity to a non-human primate species supports clinical trial design
Page 9
Partnered Programs in Phase 2 Clinical Development
| Program | Partner | Disease | Target | Status | |
|---|---|---|---|---|---|
| n.d. | Novartis | n.d. | n.d. | Clinical proof of concept achieved | |
| CNTO888 | Centocor Ortho Biotech |
Oncology | CCL2 (MCP-1) |
Two trials ongoing, one trial completed |
|
| CNTO888 | Centocor Ortho Biotech |
Idiopathic pulmonary fibrosis |
CCL2 (MCP-1) |
One trial ongoing | |
| Gantenerumab | Roche | Alzheimer"s disease |
Amyloid-b | Study in patients with prodromal AD |
|
| BHQ880 | Novartis | Osteolytic bone disease |
DKK-1 | Early data show stimulation of bone formation (three trials ongoing) |
|
| BYM338 | Novartis | Musculoskeletal | n.d. | Two phase 2 trials ongoing |
Current Pipeline Projected HuCAL Drugs on the Market
Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development
Proven Technology Platform for Making Human Therapeutic Antibodies
Novel Technologies For Unearthing New Antibody Drugs
AbD Serotec Segment Complements Therapeutic Business
Antibodies for research and diagnostic markets
Diagnostic Antibodies
- Using proprietary technologies to deliver superior Dx antibodies
- Future upside via royalties
Research Antibodies
- Catalogue of 15,000+ products & custom HuCAL antibodies
- Stable and recurring cash flows
| EUR millions | Guidance 2011 | 2010 | |
|---|---|---|---|
| AbD Serotec Segment Revenues | 22 - 23 |
20.2 | |
| AbD Serotec Profit Margin | ~ 4% | 6% |
P&L and Guidance 2011
| EUR millions | 2010 | Guidance 2011 | H1 2011 |
|---|---|---|---|
| Revenues | 87.0 | 105 – 110 |
66.6 |
| Total Operating Expenses | 77.4 | 43.5 | |
| Proprietary R&D Expenses | 26.3 | 40 – 45 |
15.2 |
| Other Operating Income | 0.2 | 0.2 | |
| Profit from Operations | 9.8 | 10 – 13 |
23.3 |
| Balance Sheet | Shareholdings by Investor Type | |||
|---|---|---|---|---|
| EUR millions | June 30, 2011 |
Dec. 31, 2010 |
Treasury Stock | |
| Assets | 0.4% | |||
| Cash, Cash Equivalents & Marketable Securities |
139.6 | 108.4 | Unidentified Management & 17% Supervisory |
|
| Other Current Assets | 21.3 | 24.1 | Board 2% Novartis |
|
| Total Non-Current Assets | 77.6 | 80.0 | Institutional 6.4% |
|
| Total Assets | 238.6 | 212.6 | 46% | |
| Liabilities | ||||
| Total Current Liabilities | 26.8 | 21.4 | Retail 28% |
|
| Total Non-Current Liabilities | 10.0 | 5.3 | ||
| Total Shareholders" Equity | 201.8 | 185.9 | ||
| Total Liabilities | 238.6 | 212.6 | Shares issued: 23,034,540 (June 30, 2011) |
Management Team
Dr. Simon E. Moroney, CEO
- Co-founder, previously at ImmunoGen
- German Cross of the Order of Merit (2002), Bavarian State Medal for Outstanding Services to the Bavarian Economy (2009)
Jens Holstein, CFO
- Joined MorphoSys in 2011
- Formerly at Fresenius: Regional CFO for region EME of Fresenius Kabi AG; several financial and general management positions at Fresenius; and in consulting industry
Dr. Arndt Schottelius, CDO
- Joined MorphoSys in 2008
- Formerly Medical Director in Immunology at Genentech Inc.; Berlex Biosciences, USA; Schering, Germany; Charité University Hospital, Berlin
Dr. Marlies Sproll, CSO
- Joined MorphoSys in 2000, promoted to CSO in 2005
- Formerly at Boehringer Ingelheim in Vienna; Merck KGaA in Darmstadt
The Pipeline What's Coming Up?
Expected dates for completion of clinical trials (MorphoSys estimates)
Forthcoming Events
MOR103
- US patent granted on MOR103
- Complete enrollment Phase 1b/2a in rheumatoid arthritis
- Start Phase 1b in multiple sclerosis
- Start clinical study of subcutaneous formulation
MOR202
- Pre-clinical data presented at ASCO
- Start Phase 1 in multiple myeloma
Partners
- 1–3 INDs ()
- Data from ongoing studies
First HuCAL antibody-based diagnostic launched
Further technology announcements
Thank You
www.morphosys.com
Dr. Simon Moroney
Chief Executive Officer
Phone +49 (0)89 / 899 27-311 Fax +49 (0)89 / 899 27-5311 Dr. Claudia Gutjahr-Löser Head of Corporate Communications & IR
Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]
HuCAL®, HuCAL GOLD®, HuCAL PLATINUM®, CysDisplay®, RapMAT® and AutoCAL® are registered trademarks of MorphoSys AG, arYla™ is a trademark of MorphoSys AG