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MorphoSys AG — Investor Presentation 2011
Nov 16, 2011
291_ip_2011-11-16_910680b4-d8d6-4736-ac1d-aa796d3c0b04.pdf
Investor Presentation
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9. WestLB Deutschland Conference
Frankfurt – November 16, 2011
This presentation includes forward-looking statements.
Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.
These and other risks and uncertainties are detailed in the Company's Annual Report.
MorphoSys – Investment Proposition
Proven Technology
Industry's most successful antibody library technology
Broad Pipeline
78 drug programs, 19 in clinical trials
Increasing Market Penetration Novel diagnostic products
Financial Strength Profitable, strong balance sheet
Experienced Management Team More than 80 years of pharma & biotech experience
Growing Pipeline Illustrates Successful Execution of Strategy
Clinical Total
Proven Technology Platform for Making Human Therapeutic Antibodies
78 Therapeutic Antibody Programs Ongoing, 19 in Clinical Trials
| Program | Partner | Indication | Discovery | Pre-clinic | Phase 1 | Phase 2 |
|---|---|---|---|---|---|---|
| MOR103 (2 programs) | - | Rheumatoid arthritis, Multiple sclerosis |
||||
| not discl. | Novartis | not discl. | ||||
| CNTO888 (2 programs) | Centocor/J&J | Cancer, Idiopathic pulmonary fibrosis |
||||
| Gantenerumab | Roche | Alzheimer's Disease | ||||
| BHQ880 | Novartis | Cancer | ||||
| BYM338 | Novartis | Musculoskeletal | ||||
| MOR208 | - | Cancer | ||||
| MOR202 | - | Cancer | ||||
| CNTO 1959 | Centocor/J&J | Psoriasis | ||||
| CNTO 3157 | Centocor/J&J | Asthma | ||||
| not discl. | Centocor/J&J | Inflammation | ||||
| not discl. | Novartis | Ophthalmology | ||||
| not discl. | Novartis | Inflammation | ||||
| not discl. | Boehringer Ingelheim | not discl. | ||||
| not discl. | Pfizer | Cancer | ||||
| OMP-59R5 | Oncomed | Cancer | ||||
| OMP-18R5 | Oncomed | Cancer | ||||
| BAY94-9343 (ADC) | Bayer HealthCare | Cancer | ||||
| 25 Partnered Programs | Various Partners | Various Indications | ||||
| 33 Programs, incl. 2 co-dev with Novartis |
Various Partners | Various Indications | 68 Partnered Programs 10 Proprietary Programs |
Current Pipeline Projected HuCAL Drugs on the Market
Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development
MOR103 Anti-GM-CSF Antibody for Inflammation
- MOR103 targets inflammatory mediator GM-CSF
- Blocks GM-CSF activity in processes central to inflammation and joint damage associated with rheumatoid arthritis
-
Pathway clinically validated
-
HuCAL antibody being developed in major indications
- Phase 1b/2a trial in rheumatoid arthritis patients ongoing
- Phase 1b trial in multiple sclerosis patients planned
-
Exclusive license to a US patent covering antibodies against GM-CSF for the treatment of chronic inflammatory conditions
-
Humanized, high-affinity anti-CD19 antibody, in-licensed from Xencor
- Comprises proprietary modification leading to rapid and sustained target cell depletion
- In clinical development for leukemia
Start Phase 1 study in CLL patients
2010 2011
MOR208
2012
MOR202 A New Anti-Cancer Antibody
- High affinity HuCAL antibody targeting CD38
- MOR202 induces killing of multiple myeloma cell lines and primary cells
- Use of targeted therapy in combination with standard regimens in myeloma can minimize adverse events while increasing efficacy through different mechanism
- Very promising pre-clinical combination data released at ASCO
AbD Serotec Segment Complements Therapeutic Business
Antibodies for research and diagnostic markets
Diagnostic Antibodies
- Using proprietary technologies to deliver superior Dx antibodies
- Future upside via royalties
Research Antibodies
- Catalogue of 15,000+ products & custom HuCAL antibodies
- Stable and recurring cash flows
| EUR millions | Guidance 2011 | 2010 |
|---|---|---|
| AbD Serotec Segment Revenues | ~20 | 20.2 |
| AbD Serotec Profit Margin | ~ 4% | 6% |
P&L and Guidance 2011
| EUR millions | 2010 | Guidance 2011 | 9M 2011 |
|---|---|---|---|
| Revenues | 87.0 | slightly below 105 | 83.7 |
| Total Operating Expenses | 77.4 | 64.1 | |
| Proprietary R&D Expenses | 26.3 | 26.1 | |
| Other Operating Income | 0.2 | 0.3 | |
| Profit from Operations | 9.8 | 10 – 13 |
19.9 |
| Balance Sheet | Shareholdings by Investor Type | |||
|---|---|---|---|---|
| EUR millions | Sep. 30, 2011 |
Dec. 31, 2010 |
||
| Assets | Treasury Stock | |||
| Cash, Cash Equivalents & Marketable Securities |
143.0 | 108.4 | 0.4% Management & |
Unidentified |
| Other Current Assets | 20.0 | 24.2 | Supervisory Board |
17% |
| Total Non-Current Assets | 76.7 | 80.0 | 2% Novartis |
|
| Total Assets | 239.7 | 212.6 | 6.4% | |
| Liabilities | ||||
| Total Current Liabilities | 29.4 | 21.4 | ||
| Total Non-Current Liabilities | 10.1 | 5.3 | Retail 28% |
|
| Total Shareholders' Equity | 200.2 | 185.9 | ||
| Total Liabilities | 239.7 | 212.6 |
Shares issued: 23,047,541 (Sep. 30, 2011)
Management Team
Dr. Simon E. Moroney, CEO
- Co-founder, previously at ImmunoGen
- German Cross of the Order of Merit (2002), Bavarian State Medal for Outstanding Services to the Bavarian Economy (2009)
Jens Holstein, CFO
- Joined MorphoSys in 2011
- Formerly at Fresenius: Regional CFO for region EME of Fresenius Kabi AG; several financial and general management positions at Fresenius; and in consulting industry
Dr. Arndt Schottelius, CDO
- Joined MorphoSys in 2008
- Formerly Medical Director in Immunology at Genentech Inc.; Berlex Biosciences, USA; Schering, Germany; Charité University Hospital, Berlin
Dr. Marlies Sproll, CSO
- Joined MorphoSys in 2000, promoted to CSO in 2005
- Formerly at Boehringer Ingelheim in Vienna; Merck KGaA in Darmstadt
Forthcoming Events
MOR103
- US patent granted on MOR103
- Complete enrollment Phase 1b/2a in rheumatoid arthritis
- Start Phase 1b in multiple sclerosis
- Start clinical study of subcutaneous formulation
MOR202
- Pre-clinical data presented at ASCO
- Start Phase 1 in multiple myeloma
Partners
- 1–3 INDs ()
- Data from ongoing studies
First HuCAL antibody-based diagnostic launched
- Further technology announcements
- New deal(s) based on Slonomics technology
Thank You
www.morphosys.com
Jens Holstein
Chief Financial Officer
Phone +49 (0)89 / 899 27-439 Fax +49 (0)89 / 899 27-5439 Dr. Claudia Gutjahr-Löser Head of Corporate Communications & IR
Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]
HuCAL®, HuCAL GOLD®, HuCAL PLATINUM®, CysDisplay®, RapMAT® and AutoCAL® are registered trademarks of MorphoSys AG, arYla™ is a trademark of MorphoSys AG