Compyp an U date

March 2010

Safe Harbour

This presentation includes forward forward-looking statements looking statements.

Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.

These and other risks and uncertainties are detailed in the Compy p an 's Annual Report.

Morp y hoS s at a Glance

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i T h t e r a p e c u	O 0 i b d b d H C A L 7 t " e r a n o p r o g r a m s a s e o n v y u S t l l i i t h h i " r o n g a a n c e s w p a r m a c o m p a n e s G f i i i b d l i t t t " r o w n g p r o p r e a r y a n o y p o r o o M i l d l i l l t t " e s o n e s a n r o a e s o n a p r o g r a m s y
/ R h e s e a r c i i D t a g n o s c s	A b D S f i b l i k t t t t " e r o e c p r o a e o g r o n g m a r e u w , I i i f D i i k t t t t " n c r e a s n g p e n e r a o n o a g n o s c s m a r e

HuCALPLATINUM: Technology p Leadership

Modular gene design & construction

HuCAL (Human Combinatorial Antibody Library)
Antibodies are fully human are
HuCAL PLATINUM launched in December 2008
Unique, built-in optimization capabilities
Robust intellectual property position

Optimization of antibodies delivers superior drug candidates

MorphoSys AG – Company Update – March 2010 © MorphoSys AG MorphoSys Page 5

HuCAL Library Design and Use (~2016 expiry) 5 US patents
2 EP patents (several EU states)

Robust Intellectual Pro

Core Patent Families

2 AU patents
Pending applications: CA EP JP US
TRInucleotide Mutagenesis (JHU excl. license) (~2013 expiry)

py y ert y Protected b

US, EP and JP patents; pending in CA
Di lfid Di l ( Disulfide Display (C Di l ys sp ay) ( 2020 i ) ) (~2020 expiry)
US, EP, AU and JP patents
Pending applications: CA EP IL NO US
Technology Development (HuCAL PLATINUM ®)
Several applications pending
Co-exclusive access to various Dyax biologics patent families
Patent applications for antibody drug candidates
Patent filings and in-licensed patents for proprietary candidates

Successful Performance in 2009

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i i F l	f € € R 8 0 8 5 " e v e n u e s o m m -		O i d b l d i i t t h " n g o n g o u e g r e v e n u e g r o w -
n a n c a f P e r o r m a n c e	O f f € € t i i t 8 1 1 " p e r a n g p r o o m m -		S f f & t h- l d R D " r o n g c a s o w u n s o w n

Propy p rietary Development: Strategic Considerations

Evaluation of potential acquisitions

Companies with antibodies in late preclinic/early clinic
Cancer & inflammation

The aim:St thMorphoSys's pipeline

Findings

No company under review passed final rengthen due diligence

Internal situation

place
Proprietary portfolio compares favorably to others'

Outcome

Acti ^e p rs it of Active pursuit acquisitions for proprietary portfolio mo ed from high moved priority activity to opportunistic
Remain open for inlicensing opportunities Experienced development team now in

HuCAL: Well-Established in Pharma Industr y

Current Product Pipeline

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d. n.	C t e n o c o r	d. n.	I f l i t n a m m a o n
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d. n.	B r S a e y h i c e r n g	C X ( A I ) M N	C a n c e r
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O M R 2 0 2	-	C D 3 8	M l t i l M l u p e y e o m a
M O R 2 0 3	-	d. n.	C a n c e r
M O R 2 0 5	-	d. n.	C a n c e r				i 7 P r o p r P r o r a m	t e a r y s
M O R 1 0 4	-	d. n.	I f l t i n a m m a o n				g
M O R 1 0 5	-	d. n.	I f l i t n a m m a o n
M O R 2 0 6	-	d. n.	C a n c e r	T t a r g e s r e	l l t c e n s e e y	d t c e
d. n.	M O R / N O V	d. n.	d. n.				1 P D r e- e v.	P r o g r a m

* Includes cancer, inflammatory, autoimmune, infectious, musculoskeletal & central nervous system diseases

Partnership yp p g s: Typical Terms per Program

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i N t t o a r s g e s v …	P f d H C A L f i 1 0 0 d i t " r e e r r e a c c e s s o o r s e n o e r s c o e r u u v v y p r o g r a m s
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P t a r n e r	S D i i h i k " a c a n y o
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Mo ho Sy A G Co rp s mp an –	Up da te Ma h 2 0 1 0 rc y –	© Mo Mo ho ho Sy Sy A G Pa 1 rp rp s s g e

N a m e	P t a r n e r	T / I d i i t t a r g e n c a o n	P h 3 a s e	M k t a r e
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d d. n n.	N t i o v a r s	d d. n n.	0 6 / 2 0 0 9 S t : a	P h 1 t r a s e
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Potential for first P-o-C data from partnered HuCAL program
4 - 6 INDs with various partners
Roche plans to move into Ph 2 in 2010 with Gantenerumab (AD); potentially others

Partnered Business: Projected HuCAL Drugs on the Market

Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development

MOR103 is a fully human HuCAL antibody targeting GM-CSF

Primary indication: rheumatoid arthritis
MOR103 blocks binding of human GM-CSF to its receptor with sub-pM affinity
Clinical material is produced using PER.C6® cell-line (Crucell/DSM)
Phase 1 successfully completed: 63 healthy volunteers double volunteers, double-blind, placebo-controlled, single ascending dose
Promising pre-clinical data for second indication

MOR103: The Opp y ortunity

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I P	B d i i h U S A t t t t t r o a p a e n p r o e c o n n e S E l i l i t t d U t t i k ƒ x c u s v e c e n s e o g r a n e p a e n c o v e r n g e y f i b d i i G M C S F t t u s e s o a n o e s a g a n s - P l i i i i b d i h l t t t t t ƒ a e n a p p c a o n s c o v e r n g a n o e s e m s e v e s P l i i i i d i i t t t t a e n a p p c a o n s c o e r n g n e n c a o n s ƒ v w

MOR103 – Ph 1b/2a (MSC-1001) in Rheumatoid Arthritis – Clinical Trial Update

Trial approved in Germany, Bulgaria, The Netherlands
Study in 135 RA patients, randomized, double-blind, placebo-controlled, multiple ascending dose
Geographic mix provides access to full spectrum from biologics-pretreated to biologics-naïve RA patients
Primary outcome measures: Adverse event rate and safety profile
Secondary outcome measures: DAS28, ACR core set measures and EULAR28 response criteria, cytokines, synovitis, bone edema, pharmacokinetics, immunogenicity and patient reported outcomes up to 16 weeks
Stable regimen of concomitant RA therapy (including anti-TNFs)

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/ P h 1 b 2 a
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i i / / F F l l P h 1 1 b b 2 2 D D t t n a a a a

MOR202: The Opp y ortunity

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M k t a r e	M l t i l l u p e m y e o m a : 1 0 % f h l i l t o e m a o o g c a c a n c e r s ƒ 1 % f l l o a c a n c e r s ƒ 2 % f d h t o c a n c e r e a s ƒ N i h i h k t t t t o c u r a v e e r a p e s o n e m a r e ƒ M d i i l 2 4 3 0 h l l i t t t e a n s r a m o n s a p a e n s ƒ u v v - , l l l t e v e n u a y r e a p s e	T i t a r g e n g a j m a o r n m e u d i l m e c a n e e
O h t e r I d i i t n c a o n s	L k i b i l d t e e m a e n g e a a e u v u

major unmet medical need

MOR202 –Development Plan

Manufacturing of clinical grade material completed according to plan
Clinical material is produced using PER.C6® p g cell-line (Crucell/DSM)
Prepare for Ph 1/2 in multiple myeloma in 2011
File CTA in Q4 2010
R ti l f t d d ti li f MOR202 Rationale for extended timeline of
Sharpened competitive profile
Longer chronic toxicity study to enable long-term clinical development
C titi d t Competitive advantage: Tox speci il bl ( ies available (cross-reacti it t tivity to non-h i t) b t human primate), robust development plan

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S T i i d t t o x c y u y
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C i i T A F l n g
S S f f P h / / 1 1 2 2 t t t t a r o a

Clinical Pipeline

Number of Partnered and Proprietary Programs at Year-end

Clinical Antibody Pipeline is ^a Key Value Driver

Opp j ortunities in Two Major Markets

Serving research market via catalog comprising over 13,000 products pg ,p industry
Building on reputation for quality
Drive uptake of HuCAL in diagnostic dust y
Exploit opportunities to create truly differentiated products

AbD Serotec –Future Prospects

Continue executing the strategy
Intensify penetration of Dx market ²⁵ y p
Keep investing in organization
Expand geographically
Strengthen direct sales force in Europe 18.2
Tighten distributor network
Mid- to long-term plan includes build-up of Asian sales team
Financials: Above market top-line growth, continuously improve margins

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A t s s e s
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T l C L i b i l i i t t t o a u r r e n a e s	2 4 3	2 7 4
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I i l l i E U R n m o n	2 0 1 0 E *	2 0 0 9 A
T l G R t o a r o u p e v e n u e s	8 9 9 3 –	8 1 0
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G O i P f i t t r o u p p e r a n g r o	5 9 –	1 1 4
S O f A b D t t i P i t M i e r o e c p e r a n g r o a r g n	% % 5 8 –	% 5
	* Es im d b t te a nu m e rs

2010

Increase of total proprietary R&D investment to € 26 – 29 million (2009: € 19.3 million)

2011 – 2012

Aiming for 10% - 20% annual revenue growth
Maintain profitability while strengthening pipeline pipeline

Shareholder Structure

Experienced Management Team

Dr. Simon E. Moroney, CEO

Prior p yg y ositions: University of Cambridge/UK, University of British Columbia/Canada, ETH Zurich/CH, ImmunoGen Inc., Associate in the Harvard Medical School, Boston/USA
Commonwealth Scholar to the University of Oxford – D. Phil. 1984
German Cross of the Order of Merit (2002), Bavarian State Medal for Outstanding Services to the Bavarian Economy (2009)

M D L CFOMr. Dave Lemus,

Joined Co in 1998 from Roche, last position: Controller and Operations Manager of 90 pharmaceutical markets
Prior positions: Group Treasurer of Lindt & Sprüngli in Zurich/CH, treasury management for Electrolux AB
B.S. (University of Maryland), M.S. (Sloan School of Management, MIT)
Certified Public Accountant (CPA) in the USA

Dr. Arndt Schottelius, CDO

Joined Morp y , , p , gy p hoSys in 2008 from Genentech Inc., SF, position: Medical Director, Immunology Development
Prior positions: Berlex Biosciences, USA; Schering, Germany; Charité University Hospital, Berlin
PhD and MD degrees from the Albert-Ludwigs-University, Freiburg/Germany
Medical studies in Germany, UK and Switzerland

Dr Marlies Sproll CSO Dr. Sproll,

Joined MorphoSys in 2000 as R&D department head, promoted to CSO in 2005
Prior positions: Vienna research facility of Boehringer Ingelheim, lab leader at Merck KGaA in Darmstadt/ Germany, involved in preclinical development of therapeutic antibodies
Ph D f th M Pl k I tit t i Tübi /G D t f N t l S i b th U i it f St tt t Ph.D. from the Max PlanckInstitute in Tübingen/Germany, Doctor of Natural Science by the University of StuttgartMorphoSys AG – Company Update – March 2010 Page 29

Goals 2010

Appendix

Sup y ervisoryBoard

Dr. Gerald MöllerChairmanM i Di t f HBM Bi V t Managing Director of BioVentures, F Di t Gl b l R h Former President Boehringer-Mannheim

Prof. Dr. Jürgen Drews Vice ChairmanFormer Director Global Research, F.Hoffmann-La Roche

Dr. Walter A. BlättlerFormer Executive Vice President Science President, CFOand Technology, ImmunoGen

Dr. Daniel Camus El i i é d F CFO, Electricitéde France, Former CFO, Aventis

Dr. Metin Colpan Supervisory Director, QIAGEN Former CEO and Founder, QIAGEN

Dr. Geoffrey Vernon Chairman, Ziggus Holding Limited Former Executive Director Rothschild Asset Management

BHQ ( 880anti-DKK-1) – Novartis Most Advanced HuCAL Compound

The Drug

H CAL ^u I G1 tib d t ti DKK IgG1 antibody, targeting DKK-1
Overexpression of DKK-1 by myeloma cells may upset the normal balance between osteoblasts and osteoclasts
Antibody vs. DKK-1 may play a role in preventing osteolytic bone disease in multiple myeloma patients

Development

Phase 1/2 study is ongoing in the US
Preclinical studies support the hypothesis that BHQ880 promotes bone the hypothesis that BHQ880 promotes formation and thereby inhibits tumor-induced osteolytic disease
A phase 1/2 combination study in combination with Zometa/Reclast in relapsed or refractory myeloma patients has started in February 2009 or February
Novartis published some early clinical results from this program at the last ASH meeting in December 2009 in Orlando
uary 2009 Date: Jan uStudy Start
Estimated E
ents ber 2010 267 mpletion D aEnrollment: Primary Co mEstimated P

BHQ880 – Public Information

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C d i t S i r e u s s e	D Y i A l- W k l r. a s r a e e
D h B k t e u s c e a n	M H l B l r. o g e r u m
D Z B k a n	D E l K r. m a r r a u s
E i I i i l S i t t t t q n e n s o n a e r c e s u u v	D M i P i k t r. a r n o s s e n e
H l e v e a	O M L A t t M D P h D r. u c e n, ,
K & C e m p e n o.	M S h i S i / M O I b d r. a c n o n r. s c a r z e o u
L d b k B B d d W W ü ü t t t t b b a n e s a n a a e e n n- r r e e m m e e r r g g	D D H F h r r. a n n s r o n m e y e r
M I D A S R h e s e a r c	M T h S h i l r. o m a s c e s s e
C N d o m u r a o e	G D W d r. a r y a a n e r s
S l. O h i a p p e n e m	D C h i i P t t r. r s a n e e r
S G S i t i e c u r e s	M R d l h B r. u o p e e s s e r v e
W L B A G t e s	D C l i T h r. o r n e a o m a s

Corporate Calendar 2010

March 23, 2010 Kempen Life Sciences Conference, Brussels, Belgium April 28, 2010 Publication of Three Months' Report 2010 May 3-5, 2010 Deutsche Bank's 35th Annual Health C C f B t USACare Conference, Boston,
May 19-20, 2010 BioEquity, Zurich, Switzerland

Thank You.

www.morphosys.com

Dave Lemus

Chief Financial Officer

Phone +49 (0)89 / 899 27-439 ( ) ( ) Fax +49 (0)89 / 899 27-5439 Email [email protected]

Dr. Claudia Gutjahr-Löser Head of Corporate Communications & IR

Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]