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MorphoSys AG Investor Presentation 2009

Sep 21, 2009

291_ip_2009-09-21_ddb73824-38f1-4098-b4d3-2915c4685645.pdf

Investor Presentation

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Rodman & RenshawAnnual Global Investment Conference

September 10, 2009

Safe Harbour

This presentation includes forward forward-looking statements. looking

Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic comp ,g y , g g etitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.

These and other risks and uncertainties are detailed in the Company's Annual Report.

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Recent Developments

Building g yp a Strong Antibody Pipeline

Current Product Pipeline: 68 Programs Ongoing

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* Includes cancer, inflammatory, autoimmune, infectious, musculoskeletal & central nervous system diseases

Partnership yp p g s: Typical Terms per Program

GantenerumabUndisclosed

  • H CAL ib d i l idβ fuCAL antibody tar getin g amyl oid-for Alzheimer's Disease
  • Two Phase 1 studies, recruitment completed

BHQ880

Partnered HuCAL Antibodies in Clinical Trials

  • HuCAL antibody targeting DKK-1 for osteolytic bone disease undisclosed)
  • Ongoing phase 1/2 study in the US

CNTO888

  • HuCAL antibody targeting the chemokine MCP-1
  • Ongoing phase 1 study in oncology
  • Ongoing phase 2 in idiopathic pulmonary fibrosis

Second HuCAL antibody to enter clinical trials within alliance with Centocor

in

HuCAL antibody for an inflammatory disease

Undisclosed

HuCAL antibody (target & indication

Ph 1 d i Q2 2009

Phase 1 commence

  • Phase 1 trial commenced in Q2 2009
  • Second HuCAL antibody to enter clinical trials within alliance with Novartis

Undisclosed

Partnered Business: Projected HuCAL Drugs on the Market

Source: MorphoSys internal statistics & Tufts Centre for the Study of Drug Development

MOR103Proprietary Inflammation Program

The Drug

  • HuCAL antibody targeting GM GM-CSF
  • GM-CSF plays a central role in inflammation
  • MOR103 blocks binding of GM-CSF to its receptor with sub-pM affinity

MOR103Clinical Development

PHASE 1 - Primary Objectives: Safety & Tolerability

Single i.v. infusion at doses up to 3 mg/kg in healthy volunteers . in volunteers were generally safe and well tolerated

Secondary Objectives: PK and Immunogenicity

  • Pharmacokinetics were generally consistent between subjects and throughout the dose range studied
  • No anti-MOR103 IgG antibodies were observed in doses up t 3 /k o mg g
  • Changes in general IgA, IgG, and IgM concentrations, if any, were similar in all groups, including placebo

PHASE 1b/2a - Trial Design

  • At least 130 Rheumatoid Arthritis patients
  • Multiple centers in several European countries to ensure robust patient recruitment

MOR202Proprietary Cancer Program

  • MOR202, a fully human HuCAL antibody, targeting CD38, a 45 kDa ectoenzyme heavily over-expressed in 95% of multiple myel d l k i ll li loma and some leukemia cell lines
  • Function: Induces cell-killing by ADCC, CDC & apoptosis
  • Primary py indication: Multiple myeloma
  • Commercial opportunity
  • 10 % of hematological cancers / 1% of all cancers / 2% of cancer deaths
  • No curative therapies
  • Median survival 24 – 30 months, all patients eventually relapse

O tl k 2009Outlook 2009:

  • Further evaluation in animal models of multiple myeloma
  • Start of non-clinical safety y pp g study to support clinical testing
  • Start of preclinical efficacy studies in second indication
  • Production and release of mAb material for animal safety testing and in preparation for phase 1/2a clinical testing in 2010

Clinical Pipeline

Number of Partnered and Proprietary Clinical Compounds at Year-End

Clinical Antibody Pipeline is a Key Value Driver

AbD Serotec: The Business

CUSTOM

  • Extending HuCAL technology into new markets

  • Increased focus on Dx

  • Over 13,000 products

  • Large customer base
  • I ibd Increasing brandawareness

Large-scale supply to Dx customers

AbD Serotec: Solid Progress

Growth

  • AbD Serotec H1 2009 revenues: +8%
  • Market growing at 3 – 5%

P fit ro

  • AbD Serotec now solidly profitable
  • Investing now for future growth

Diagnostics

  • First HuCAL antibody in a diagnostic kit ( (Phadia)
  • Multiple diagnostic projects ongoing

Management

  • Dieter Feger, SVP – new head of unit
  • 20 years in sales & marketing at Abbott Diagnostics marketing DiagnosticsMorphoSys AG – Company Update – September 2009 Page 17

MorphoSys Group Financial Guidance 2009

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► I f t t l i t R&D i t t t EUR 18 Increase o total proprietary investment to – 20 million (2008: EUR 7.7 million)

MorphoSys Group Outlook

  • Aiming for 10%–20% annual revenue growth
  • M i t i fit bilit hil t th i i li aintain profit ability, while strengthening pipeline

Shareholder Structure and Key Financials

Shareholder Structure

Key Financials (H1 2009)

25.

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New deals (alliances, partnerships, in-licensing…)

Thank You.

www.morphosys.com

Dr. Simon Moroney

Chief Executive Officer

Phone +49 (0)89 / 899 27-311 ( ) ( ) Fax +49 (0)89 / 899 27-5311 Email [email protected]

Dr. Claudia Gutjahr-Löser Head of Corporate Communications & IR

Phone +49 (0)89 / 899 27-122 Fax +49 (0)89 / 899 27-5122 Email [email protected]

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