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MorphoSys AG — Investor Presentation 2007
Jun 20, 2007
291_ip_2007-06-20_ed5205e4-7757-43b0-acbb-f07c846dd984.pdf
Investor Presentation
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10th German Corporate Conference
Frankfurt – June 20, 2007
Safe Harbour
This presentation includes forward-looking statements.
Actual results could differ materially from those included in the forward-looking statements due to various risk factors and uncertainties including changes in business, economic competitive conditions, regulatory reforms, foreign exchange rate fluctuations and the availability of financing.
These and other risks and uncertainties are detailed in the Company's Prospectus.
The MorphoSys Group Today
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MorphoSys Businesses and Strategy
HuCAL: World Leading Antibody Technology
- Antibodies can be…systematically optimized to match therapeutic application
- Antibodies are…fully human
- High throughput provides… economy of scale for research uses
- Proprietary to MorphoSys
HuCAL
(Human Combinatorial Antibody Library): A vast collection or "library" of over 12 billion human antibodies in a system that enables systematic optimization of antibody properties
Robust Intellectual Property Protected by Core Patent Families
HuCAL Library Design and Use (~2016 expiry)
- 4 US Patents
- 1 EU Patent (numerous EU states)
- 1 AU Patent
- Pending applications: CA EU JP US
- TRInucleotide Mutagenesis (JHU excl license) (~2012 expiry)
- 1 US Patent; EP upheld in amended form; pending in JP
Disulfide Display (CysDisplay) (~2020 expiry)
- 1 US Patent
- EU application in late stage prosecution
- Pending applications: AU CA EU IL JP NO US
Various Patent Applications on:
- Ancillary technologies
- Individual antibodies
Corporate Structure Mirrors Strategy
Acquisitions Prove Importance of Antibodies to Big Pharma
Therapeutic Antibody Partnerships
- Partner provides target, initiates program, brings disease-specific expertise
- Responsibilities
| O M R |
P t a r n e r |
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|---|---|---|
| L d i t e a g e n e r a o n |
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- Programs exclusive on "per target" basis
- Partnerships typically multi-year, often multi-target
Therapeutic Antibody Partnerships: Typical Program Deal Terms
Long-Term, Blue-Chip Relationships
Renewals, expansions, extensions
Number of active, partnered HuCAL programs at the end of each year
Roche's Alzheimer Program
- Drug: R1450, a HuCAL antibody made & optimized at MorphoSys
- Phase 1 Trials
Trial 1
- Randomized, double-blind, multiple ascending dose study in patients
- Target sample size is <100 individuals
Trial II
- Randomized, double-blind, single dose study in patients
- Target sample size is <100 individuals
Conducted in Denmark, Netherlands, Sweden and the UK
First results expected 2008 (MorphoSys estimate)
GPC Biotech's Cancer Program
- Phase 1 Trial
- At three European sites, in patients
- Preliminary clinical phase I data showed:
- Drug is well tolerated
- First hints of anti-tumor activity
- GPC has communicated that completion of dose escalating study is expected shortly
- Drug has orphan status in CLL, MM, and Hodgkin's lymphoma
maximize pipeline value
Proprietary Drug Investment: The Rationale
- Pipeline weakness is making pharma desperate for new drug candidates
- Recent deals show that pharma is prepared to value an IND-stage drug at \$100 million
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MorphoSys makes selective investments in proprietary drugs to
MOR103: A HuCAL Antibody for Rheumatoid Arthritis (RA)
Medical Need
RA patients adequately treated: Under 25% Non-responders to anti-TNFs: 30% Non-responders after 2 years on anti-TNF: 50% Long-term safety issues with anti-TNFs Drug Candidate HuCAL antibody vs. undisclosed target Very high affinity and expression: potential CoGS advantage Potential in other inflammatory indications
Milestones
- H2 2006: Manufacturing agreement with Crucell/DSM ;
- H2 2007: Planned filing for phase I clinical trial
MOR202: A HuCAL Antibody for Multiple Myeloma (MM)
Medical Need
- MM accounts for 10-15% of hematological & 1% of all cancers
- Few available treatment options, no curative therapies
- New agents, Velcade and Revlimid, have efficacy (nonresponders) and safety issues
Drug Candidate
- HuCAL antibodies vs. CD 38, a 45kDa glycoprotein
- Over-expressed on MM (95%) and some leukemia cell-lines
- Compelling efficacy data in vitro and in vivo (SCID mouse)
- Mechanism is ADCC plus effector cell independent
Milestones
- End 2006: Lead candidate selected;
- 2007: Define therapeutic window and effective dose level, stability study
Corporate Structure Mirrors Strategy
AbD Serotec: The Business
AbD Serotec: Gaining Scale
| I E U R i l l i n m o n s |
2 0 0 7 |
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|---|---|---|---|
| R e v e n u e s |
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| S T h i A i b d i t t t e g m e n e r a p e u c n o e s |
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Guidance
Financial Growth
| 2 0 0 6 |
5 2 0 0 |
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* Differences due to rounding
Profit & Loss Statement (Group) Q1 2007
Cash position today > EUR 100 million (Capital Increase in May '07)
* Differences due to rounding
In EUR millions
Securities
Assets
Liabilities
Shareholder Structure
- Institutional Shareholders
- Novartis
- AstraZeneca
- Management & Supervisory Boards
- Retail & Others
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| N i " t o v a r s |
7 % ~ |
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8 8 % ~ |
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| R i l & O h " t t e a e r s |
4 4 % ~ |
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| M & S i B d " t a n a g e m e n u p e r v s o r y o a r s |
2 5 % ~ |
Group
- Revenue EUR 60 65 million (2/3 therapeutics: 1/3 research products)
- Operating profit EUR 7 10 million
Therapeutic Segment
- MOR103 IND
- With partners:
- 1-3 INDs
- 50 therapeutic programs by year-end
- New / expanded partnerships
AbD Serotec
- Over 20% revenue growth
- EBIT margin: 5 - 10%
- New marketing alliance to drive uptake of HuCAL in research community
Thank You.
www.morphosys.com
HuCAL®, HuCAL GOLD® and CysDisplay® are registered trademarks of MorphoSys AG, RapMATTM and AutoCALTM are trademarks of MorphoSys AG