Microbix Biosystems Inc. — Regulatory Filings 2021

Feb 19, 2021

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Notice and Access Notification for 2021 Annual and Special Meeting of Shareholders

Dear Shareholder:

You are receiving this notification as a beneficial shareholder of Microbix Biosystems Inc. (the “Company”). The Company has elected to use the notice and access mechanism for delivery of its 2021 proxy related materials for the upcoming annual and special meeting of shareholders (the “Meeting”). This process directly benefits the Company through a substantial reduction in both postage and material costs and also helps the environment through a decrease in paper documents that are ultimately discarded.

An electronic copy of the management information circular (the “Circular”) related to this Meeting may be found at and downloaded from www.meetingdocuments.com/ASTca/MBX. We have added features that will make searching for relevant sections and specific items a much easier process than finding this information in the paper versions of these documents. The proxy related materials are also available on the Company’s SEDAR profile at www.sedar.com.

The Meeting:

MICROBIX BIOSYSTEMS INC. Annual and Special Meeting of Shareholders March 30, 2021 at 1:00 p.m. ET, via Zoom: - https://us02web.zoom.us/webinar/register/WN_H982AmbSQ_ bCm1u5_p2nw

The following matters will be reviewed and voted upon at this Meeting:

• Election of Directors, as detailed in the “Election of Directors” section of the circular;

• Appointment of Auditors, as detailed in the “Appointment of Auditors” section of the Circular;

• Re-approval of the Company’s Stock Option Plan, as detailed in the “Special Business” section of the Circular;

• Approval of amendment to Warrants held by Insiders of the Company, as detailed in the “Special Business” section of the Circular; and

• Other business as may be properly brought before the Meeting.

Voting:

You have a number of options to vote your registered Proxy:

• Cast your vote on the Internet at www.ASTvotemyproxy.com and follow the instructions on screen

• Cast your vote by telephone at 1-888-489-5760

• Fax your signed Proxy to 1-866-781-3111

• Return your signed Proxy by mail using the enclosed business reply envelope

• Scan and send your signed Proxy to proxyvote@astfinancial.com

If you will cast your vote via Internet or telephone, you will need your 13-digit control number. You will find your control number on your Proxy. However you choose to vote, we must receive your vote by 5:00 p.m. ET on March 26, 2021 (the “proxy cut-off deadline”). We also strongly encourage you to first review the matters under discussion for the Meeting as described in our Circular.

Paper Copies:

Should you wish to receive a paper copy of the Circular related to this Meeting, or have any questions, please contact our transfer agent AST Trust Company (Canada) at 1-888-433-6443 from Canada and the United States at 416-682-3801 or fulfilment@astfinancial.com and we will send a copy within three business days, giving you sufficient time to vote your Proxy. Following the meeting the documents will remain available at the website listed above for a period of one year.