MAYNE PHARMA GROUP LIMITED — Director's Dealing 2008

Feb 19, 2008

Appendix 3Y Change of Director’s Interest Notice

Rule 3.19A.2

Appendix 3Y

Change of Director’s Interest Notice

Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX become ASX’s property and may be made public.

Introduced 30/9/2001.

Name of entity	HalcyGen Pharmaceuticals Limited
ABN	76 115 832 963

We (the entity) give ASX the following information under listing rule 3.19A.2 and as agent for the director for the purposes of section 205G of the Corporations Act.

Name of Director	Bruce Mathieson
Date of last notice	15 February 2008

Part 1 - Change of director’s relevant interests in securities

In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust

Note: In the case of a company, interests which come within paragraph (i) of the definition of “notifiable interest of a director” should be disclosed in this part.

Direct or indirect interest	Direct and Indirect interest
Nature of indirect interest(including registered holder)Note: Provide details of the circumstances giving rise to the relevantinterest.	1) Mr Bruce Mathieson2) Mrs Jill Mathieson3) Investment Holdings Pty Ltd4) BLM Superannuation Nominees Pty Ltd
Date of change	15, 18 & 19 February 2008
No. of securities held prior to change	250,000Ordinary Fully Paid Shares (2)2,489,968 Ordinary Fully Paid Shares (3)1,090,000 Ordinary Fully Paid Shares (4)250,000Unlisted options for ordinaryshares @ 60 cents expiring 17April 2011 (1)
Class	Ordinary fully paid shares
Number acquired	145,290 (3)
Number disposed	Nil
Value/ConsiderationNote: If consideration is non-cash, provide details and estimatedvaluation	$51,131.19

• See chapter 19 for defined terms.

11/3/2002

Appendix 3Y Page 1

Appendix 3Y Change of Director’s Interest Notice

No. of securities held after change	250,000	Ordinary Fully Paid Shares (2)
	2,635,258	Ordinary Fully Paid Shares (3)
	1,090,000	Ordinary Fully Paid Shares (4)
	250,000	Unlisted options for ordinary
		shares @ 60 cents expiring 17
		April 2011 (1)
Nature of change	On Market	acquisition of ordinary shares
Example: on-market trade, off-market trade, exercise of options, issue of
securities under dividend reinvestment plan, participation in buy-back

Part 2 – Change of director’s interests in contracts

Note: In the case of a company, interests which come within paragraph (ii) of the definition of “notifiable interest of a director” should be disclosed in this part.

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----- Start of picture text ----- Detail of contractNature of interestName of registered holder(if issued securities)Date of changeNo. and class of securities towhich interest related prior tochangeNote: Details are only required for a contract in relationto which the interest has changedInterest acquiredInterest disposedValue/ConsiderationNote: If consideration is non-cash, provide details andan estimated valuationInterest after change----- End of picture text -----

• See chapter 19 for defined terms.

Appendix 3Y Page 2

11/3/2002