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MaaT Pharma
Regulatory Filings • Nov 9, 2021
1494_iss_2021-11-09_d9e34e6e-0a7e-41a4-9db2-a572359e0202.pdf
Regulatory Filings
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MaaT Pharma to Provide Additional Results from Phase II Trial and Expanded Access Program on MaaT013 in Oral Presentation at 63rd American Society of Hematology (ASH) Annual Meeting
- Results from HERACLES trial in 24 patients with GI-predominant, steroid-resistant grade III-IV aGvHD and from EAP program in 52 patients with aGvHD with GI involvement having failed previous therapies
- MaaT013, the Company's lead drug candidate, is a high-richness, high-diversity Microbiome Ecosystem Therapy (MET).
Lyon, France, November 9, 2021, 6 pm CET – MaaT Pharma (EURONEXT: MAAT - the "Company"), a French clinical-stage biotech and a pioneer in the development of microbiome-based ecosystem therapies dedicated to improving survival outcomes for patients with cancer, announced today that additional results from its Phase 2 trial HERACLES (NCT03359980) and extended results from its compassionate use (EAP) program for lead microbiome therapeutic MaaT013 will be discussed in an oral presentation at the 63 rd American Society of Hematology (ASH) Annual Meeting held from December 11-14, 2021. With these additional data from its MaaT013 Phase 2 trial and from MaaT013 early access program, this is the second year that results from the Company are selected for an oral presentation, and the fifth year in a row that the Company presents data at the ASH conference.
The HERACLES results include data from 24 patients with grade III-IV, steroid-resistant, gastrointestinal (GI)-predominant, acute Graft-versus-Host-Disease (aGvHD) that were treated with MaaT013 as second line therapy. The EAP results include data from 52 patients treated with MaaT013, with steroid-resistant or steroid-dependent aGvHD with GI involvement, who had previously failed 1 to 6 lines (median: 3) lines of systemic therapy; MaaT Pharma provided the product to hospitals under a compassionate access program in France ("accès compassionnel"- EAP). MaaT013 is a high-richness, high-diversity Microbiome Ecosystem Therapy (MET) derived from pooled donations from strictly vetted healthy individuals and is presented as an enema.
The data will be presented by Prof. Mohamad Mohty, professor and head of the Hematology and Cellular Therapy Department at the Saint-Antoine Hospital and Sorbonne University.
Oral Presentation details:
Title: Pooled Allogenic Fecal Microbiotherapy MaaT013 for the Treatment of Steroid-Refractory Gastrointestinal Acute Graft-Versus-Host Disease: Results from the Phase IIa Heracles Study and Expanded Access Program
Abstract No: 262
Session Name: 722. Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: Treatment of acute and chronic graft vs. host disease
Date/Time: Saturday, December 11, 2021; 2:45 PM EST
Room: Georgia World Congress Center, B304-B305
MaaT Pharma will announce the results through a press release on Monday, December 13, 2021.
About MaaT Pharma
MaaT Pharma, a clinical stage biotechnology company, has established a complete approach to restoring patient-microbiome symbiosis in oncology. Committed to treating cancer and graft-versushost disease (GvHD), a serious complication of allogeneic stem cell transplantation, MaaT Pharma has already achieved proof of concept in a Phase II clinical trial in acute GvHD. Our powerful discovery and analysis platform, gutPrint®, supports the development and expansion of our pipeline by determining novel disease targets, evaluating drug candidates, and identifying biomarkers for microbiome-related conditions.
The company's Microbiome Ecosystem Therapies are produced through a standardized cGMP manufacturing and quality control process to safely deliver the full diversity of the microbiome, in liquid and oral formulations. MaaT Pharma benefits from the commitment of world-leading scientists and established relationships with regulators to support the integration of the use of microbiome therapies in clinical practice.
MaaT Pharma is listed on Euronext Paris (ticker: MAAT).
Contacts
MaaT Pharma Hervé AFFAGARD Co-Founder and CEO +33 4 28 29 14 00 haffagard@maatpharma.com
ACTIFIN, Financial Communication Ghislaine GASPARETTO +33 (0)6 21 10 49 24 [email protected] MaaT Pharma Pauline RICHAUD Corporate Communication Manager +33 6 07 55 25 36 [email protected]
Trophic Communications Corporate Communication Jacob VERGHESE or Gretchen SCHWEITZER +49 89 23 88 77 31 [email protected]