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LYSOGENE Capital/Financing Update 2021

Jul 5, 2021

1492_rns_2021-07-05_af7d1194-3606-4503-944d-9c4201017965.pdf

Capital/Financing Update

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PRESS RELEASE

Half-year liquidity contract statement for LYSOGENE

Paris, France — 05 July 2021 at 06:00 pm CEST — Lysogene (FR0013233475 – LYS), a phase 3 gene therapy platform Company targeting central nervous system (CNS) diseases, today presents the half-year report on the liquidity contract signed by Lysogene with Kepler Cheuvreux.

Under the liquidity contract entered into between LYSOGENE and Kepler Cheuvreux, the following resources appeared on the liquidity account on June 30th 2021:

  • 43,579 shares
  • € 132,063.33
  • Number of executions on buy side on semester: 369
  • Number of executions on sell side on semester: 399
  • Traded volume on buy side on semester: 125,130 shares for € 358,888.31
  • Traded volume on sell side on semester: 131,937 shares for € 400,135.60

As a reminder:

  • the following resources appeared on the last half year statement on 31 December 2020 on the liquidity account:
  • 50,386 shares
  • € 91,098.95
  • Number of executions on buy side on semester: 303
  • Number of executions on sell side on semester: 278
  • Traded volume on buy side on semester: 96,720 shares for € 217,955.50
  • Traded volume on sell side on semester: 90,522 shares for € 215,280.25
  • the following resources appeared on the liquidity account when the activity started:
  • 34,030 shares
  • € 78,185.94

The liquidity agreement complies with AMF Decision n° 2018-01 dated 2nd July 2018, introducing liquidity agreements on equity securities as permitted market practice.

AS

Alyscgene

Number of
executions
Number of
shares
Traded
volume (€)
Numbe
executio
Total 369 125,130 358,888.31
04/01/2021
05/01/2021 7 3 3 9 9 9 143.31
06/01/2021 1 500 1 325.00
07/01/2021
08/01/2021 6 1 500 3 900.00
11/01/2021
12/01/2021 6 4 500 12 420.00
13/01/2021 7 4 0 0 0 10 640.00
14/01/2021 1 500 1 325.00
15/01/2021 2 1 000 2 580.00
18/01/2021 6 1 500 3750.00
19/01/2021 1 500 1 250.00
20/01/2021 4 1 0 0 0 2 480.00
21/01/2021
22/01/2021 6 1500 3750.00
25/01/2021 16 5 0 0 0 11 700.00
26/01/2021 2 500 1 150.00
27/01/2021
28/01/2021 4 2 0 0 0 4 620.00
29/01/2021 3 500 1 150.00
01/02/2021
02/02/2021 1 500 1 250.00
03/02/2021
04/02/2021
05/02/2021 4 1 500 4 200.00
08/02/2021
09/02/2021 9 2700 8 343.00
10/02/2021 7 2 0 0 0 5 960.00
11/02/2021 3 1 0 0 0 2 900.00
12/02/2021 2 1 0 0 0 3 680.00
15/02/2021 2 500 1925.00
16/02/2021 21 6536 24 117.84
17/02/2021 14 6 2 2 1 21 586.87
18/02/2021 16 6804 21 772.80
19/02/2021 3 1500 4 635.00
22/02/2021 2 1 0 0 0 3 230.00
Sell Side
Number of
executions
Number of
shares
Traded
volume (€)
399 131,937 400,135.60
15 2500 7 025.00
1 500 1 425.00
2 500 1 370.00
1 500 1 370.00
3 500 1 350.00
15 9500 29 450.00
- -
- -
1 500 1 300.00
1 500 1 275.00
6 1500 3825.00
$\overline{a}$
1 150 375.00
1 500 1 175.00
4 2000 4 980.00
-
15 7000 17 500.00
1 500 1 300.00
16 5000 13 400.00
14 5000 14 550.00
6 1500 4 4 2 5 . 0 0
14 5000 15 400.00
-
2 1000 3 140.00
18 9069 29 111.49
33 7500 27 900.00
20 7000 29 540.00
1 500 1850.00
-
9 3000 9840.00
8 2000 6760.00

Alyscgene

Alyscgene

Buy Side Sell Side
Number of
executions
Number of
shares
Traded
volume (€)
Number of
executions
Number of
shares
Traded
volume (€)
23/02/2021 23 4 500 14 985.00 4 2000 7 160.00
24/02/2021 1 500 1 625.00 3 1000 3 280.00
25/02/2021 12 4000 13 640.00
26/02/2021 9 3 500 11 410.00 $\overline{7}$ 1000 3 380.00
01/03/2021 6 1157 3899.09
02/03/2021 2 500 1 645.00
03/03/2021 6 2 0 0 0 6 380.00
04/03/2021 11 3 500 10 815.00
05/03/2021 5 1 500 4 500.00
08/03/2021 2 500 1 475.00 $\overline{2}$ 500 1 510.00
09/03/2021 1 500 1 475.00 8 2006 6 278.78
10/03/2021 1 500 1 550.00 3 494 1 556.10
11/03/2021 1 500 1 575.00
12/03/2021 3 500 1 575.00
15/03/2021 2 1 0 0 0 3 060.00
16/03/2021 1 500 1 500.00
17/03/2021 3 1000 3 030.00
18/03/2021 3 500 1 495.00
19/03/2021 10 2 0 0 0 5760.00
22/03/2021 3 1 0 0 0 2 880.00 3 1000 2 930.00
23/03/2021 1 500 1 425.00
24/03/2021 2 1 0 0 0 2780.00 $\overline{a}$
25/03/2021 4 1 0 0 0 2 730.00 1 500 1420.00
26/03/2021 $\overline{2}$ 500 1 375.00
29/03/2021 4 1000 2 830.00
30/03/2021 1 500 1 400.00 4 500 1 450.00
31/03/2021 3 1000 2 880.00
01/04/2021 1 500 1 395.00 1 500 1 425.00
06/04/2021 2 500 1 400.00
08/04/2021 1 $\mathbf{1}$ 2.79 $\mathbf{2}$ 501 1 402.80
09/04/2021 $\overline{2}$ 500 1 400.00 1 500 1 425.00
12/04/2021 1 500 1 400.00
13/04/2021 3 1500 4 350.00
14/04/2021 $\overline{2}$ 1 0 0 0 2 880.00 $\blacksquare$ ۰
15/04/2021 $\overline{2}$ 201 570.84

Jyscgene

Buy Side Sell Side
Number of
executions
Number of
shares
Traded
volume (€)
Number of
executions
Number of
shares
Traded
volume $(\epsilon)$
16/04/2021 1 $\overline{7}$ 20.30
19/04/2021 $\frac{1}{2}$ $\overline{\phantom{a}}$ 1 493 1 429.70
20/04/2021 3 500 1 400.00
21/04/2021 1 500 1 375.00
22/04/2021 3 1 0 0 0 2 930.00 9 3000 8 940.00
23/04/2021 4 1 500 4 260.00 $\overline{a}$
26/04/2021 1 500 1 400.00 $\overline{a}$ $\blacksquare$
27/04/2021 2 500 1 400.00 3 500 1 425.00
28/04/2021 $\overline{4}$ 1000 2 830.00
29/04/2021 3 500 1 400.00 $\overline{\phantom{0}}$ $\blacksquare$
30/04/2021 4 500 1 375.00
03/05/2021 $\boldsymbol{2}$ 500 1 400.00
06/05/2021 1 500 1 375.00 $\blacksquare$ $\blacksquare$
07/05/2021 ÷, $\overline{2}$ 500 1 375.00
11/05/2021 9 2 0 0 0 5 260.00 1 500 1 325.00
12/05/2021 4 1 500 3 825.00 $\overline{a}$
13/05/2021 6 2 0 0 0 4 960.00
14/05/2021 14 4000 10 760.00
17/05/2021 2 500 1 300.00 $\mathbf{1}$ 500 1 350.00
18/05/2021 1 1 2.63 3 226 598.90
19/05/2021 1 1 2.63 1 1 2.63
20/05/2021 4 500 1 275.00 $\overline{a}$
24/05/2021 4 1 0 0 0 2 580.00 3 775 2 030.50
25/05/2021 $\overline{7}$ 2 0 0 0 4 960.00 1 500 1 300.00
26/05/2021 7 1 500 3 630.00 $\overline{2}$ 272 680.00
27/05/2021 3 1500 3 525.00
02/06/2021 1 500 1 175.00
03/06/2021 $\qquad \qquad \blacksquare$ $\overline{\phantom{a}}$ $\sqrt{2}$ 1000 2 430.00
04/06/2021 4 500 1 200.00 - $\qquad \qquad \blacksquare$
07/06/2021 ÷, $\mathbf 5$ 728 1798.16
08/06/2021 $\overline{7}$ 2500 6 575.00
09/06/2021 8 3869 9788.57 $\blacksquare$
10/06/2021 ÷, $\overline{\phantom{a}}$ 13 5000 13 300.00
11/06/2021 ٠ 21 9000 27 000.00
14/06/2021 3 1 500 4 275.00 ÷ $\overline{\phantom{a}}$
15/06/2021 3 2 0 0 0 5 520.00 4 1000 2 930.00
16/06/2021 10 4896 12 729.60 $\mathbf{1}$ 500 1 400.00

Alyscgene

Buy Side Sell Side
Number of
executions
Number of
shares
Traded
volume (€)
Number of
executions
Number of
shares
Traded
volume (€)
17/06/2021 5 2 000 4 980.00 - - -
18/06/2021 2 1 000 2 430.00 2 500 1 250.00
21/06/2021 1 500 1 175.00 - - -
22/06/2021 - - - 4 1000 2 430.00
23/06/2021 1 1 2.43 4 1501 3 752.50
24/06/2021 - - - 2 1000 2 480.00
25/06/2021 2 500 1 200.00 - - -
28/06/2021 2 500 1 175.00 1 57 139.65
30/06/2021 2 1 000 2 280.00 1 500 1 175.00

About Lysogene

Lysogene is a gene therapy Company focused on the treatment of orphan diseases of the central nervous system (CNS). The Company has built a unique capability to enable a delivery of gene therapies to the CNS to treat lysosomal diseases and other genetic disorders of the CNS. A phase 2/3 clinical trial in MPS IIIA in partnership with Sarepta Therapeutics, Inc. is ongoing. An adaptive clinical trial in GM1 gangliosidosis is ongoing. In accordance with the agreements signed between Lysogene and Sarepta Therapeutics, Inc., Sarepta Therapeutics, Inc. will hold exclusive commercial rights to LYS-SAF302 in the United States and markets outside Europe; and Lysogene will maintain commercial exclusivity of LYS-SAF302 in Europe. Lysogene is also collaborating with an academic partner to define the strategy of development for the treatment of Fragile X syndrome, a genetic disease related to autism. www.lysogene.com.

Forward Looking Statement

This press release may contain certain forward-looking statements, especially on the Company's progress of its clinical trials and cash runway. Although the Company believes its expectations are based on reasonable assumptions, all statements other than statements of historical fact included in this press release about future events are subject to (i) change without notice, (ii) factors beyond the Company's control, (iii) clinical trial results, (iv) increased manufacturing costs and (v) potential claims on its products. These statements may include, without limitation, any statements preceded by, followed by or including words such as "target," "believe," "expect," "aim," "intend," "may," "anticipate," "estimate," "plan," "objective", "project," "will," "can have," "likely," "should," "would," "could" and other words and terms of similar meaning or the negative thereof. Forward-looking statements are subject to inherent risks and uncertainties beyond the Company's control that could cause the Company's actual results, performance or achievements to be materially different from the expected results, performance or achievements expressed or implied by such forward-looking statements. A further list and description of these risks, uncertainties and other risks can be found in the Company's regulatory filings with the French Autorité des Marchés Financiers, including in the 2020 universal registration document, registered with the French Markets Authorities on April 12, 2021, under number D.21-0296, and future filings and reports by the Company. Furthermore, these forward-looking statements are only as of the date of this press release. Readers are cautioned not to place undue reliance on these forward-looking statements. Except as required by law, the Company assumes no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially

from those anticipated in the forward-looking statements, even if new information becomes available in the future. If the Company updates one or more forward-looking statements, no inference should be drawn that it will or will not make additional updates with respect to those or other forward-looking statements.

This press release has been prepared in both French and English. In the event of any differences between the two texts, the French language version shall supersede.

Contacts Stéphane Durant des Aulnois Chief Financial Officer [email protected] + 33 1 41 43 03 99