Lifecare ASA

Regulatory Filings • Oct 8, 2024

LIFE Longevity trial: Biopsy and bacteriological examination confirm no unexpected foreign body reactions after removal of implant

LIFE Longevity trial: Biopsy and bacteriological examination confirm no unexpected foreign body reactions after removal of implant

Bergen, Norway, 08 October 2024: Today, Lifecare ASA (LIFE), a clinical stage

medical sensor company developing the next generation Continuous Glucose

Monitor (CGM), can confirm no unexpected tissue or body response based on

bacteriological and biopsy tests after removal of the implanted sensor used in

first longevity study. In addition, post study testing of the sensor in-vitro

confirm intact glucose-sensitivity.

Reference is made to the press release from 11 September 2024 when the company

announced the successful completion of the first veterinary patient in the

longevity trial after 12 weeks. The sensor was removed in accordance with the

regulatory approved protocol. Lifecare's team has now completed a thorough

analysis of both the surrounding tissue and the implant, after removal.

Prior to implanting the sensor in late June, the glucose sensitivity of the

implant was tested and due to good results declared ready for the

implantation. After 12 weeks of implantation the implant was removed from the

dog.

Biopsies and bacteriological tests of tissue surrounding the sensor under

Elli's skin conducted at Norwegian University of Life Sciences (NMBU), shows

no swelling and infection in the wound post-operatively and no adverse effects

in the dog.

In-vitro functionality tests of the implant after removal have shown that the

sensor is fully glucose sensitive. The scientific team has concluded that the

implant was stable over the period of 12 weeks.

- We are especially pleased that the biopsies and bacteriological examinations

confirm the visual inspections during the removal of the implant after 12

weeks, showing no unexpected foreign body reactions. The primary goal of the

first sensor in the longevity trial was to investigate foreign body reactions

and to confirm the sensors operational lifespan in a long-term perspective.

These goals have been met in this first part of the study, says Holter.

- Retrieving the sensor from Elli has provided a valuable insight to further

understand the sensor's characteristics and helped identify potential areas

for improvement. We are also very pleased to report that biopsy tests show no

signs of adverse effects in our first patient of our longevity trial, says Jo

Amundstad at Lifecare Veterinary.

Lifecare plan to initiate the next phase of testing in the upcoming weeks, the

initiation is subject to internal quality control of produced sensors and

bacteriological tests prior to implantation.

About us

Lifecare ASA is a clinical stage medical sensor company developing technology

for sensing and monitoring of various body analytes. Lifecare's main focus is

to bring the next generation of Continuous Glucose Monitoring ("CGM") systems

to market. Lifecare enables osmotic pressure as sensing principle, combined

with the ability to manipulate Nano-granular Tunnelling Resistive sensors

("NTR") on the sensor body for read-out of pressure variations. Lifecare's

sensor technology is referred to as "Sencell" and is suitable for identifying

and monitoring the occurrence of a wide range of analytes and molecules in the

human body and in pets.

Contacts

For further information, please contact:

Joacim Holter, CEO, joacim.holter@lifecare.no, +47 40 05 90 40

Renete Kaarvik, CFO, renete.kaarvik@lifecare.no, +47 94 83 82 42