LEXICON PHARMACEUTICALS, INC. — Proxy Solicitation & Information Statement 2010

Mar 19, 2010

DEFA14A 1 proxynotice2010.htm proxynotice2010.htm Licensed to: Lexicon Pharmaceuticals Document Created using EDGARizer 5.1.4.0 Copyright 1995 - 2009 Thomson Reuters. All rights reserved.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, DC. 20549

SCHEDULE 14A

(Rule 14A-101)

INFORMATION REQUIRED IN PROXY STATEMENT

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of

the Securities Exchange Act of 1934

Filed by the Registrant x

Filed by a Party other than the Registrant

Check the appropriate box:

| o | Preliminary Proxy Statement | Confidential, for Use of the Commission Only | | --- | --- | --- | | o | Definitive Proxy Statement | (as permitted by Rule 14a-6(e)(2)) | | x | Definitive Additional Materials | | | o | Soliciting Material Pursuant to Rule 14a-11(c) or Rule 14a-12 | |

| LEXICON

PHARMACEUTICALS, INC.
( Name o f Registrant as Specified In Its Charter)
(Name of
Person(s) Filing Proxy Statement, if Other Than the
Registrant)

Payment of Filing Fee (Check the appropriate box):

x No fee required.

o Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.

| (1) | Title of each class of securities to which transaction applies: N/A | | --- | --- | | (2) | Aggregate number of securities to which transaction applies: N/A | | (3) | Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined): N/A | | (4) | Proposed maximum aggregate value of transaction: N/A | | (5) | Total fee paid: $0 |

| o | Fee paid previously with preliminary materials: N/A | | --- | --- | | o | Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing. |

| (1) | Amount Previously Paid: | | --- | --- | | (2) | Form, Schedule or Registration Statement No.: | | (3) | Filing Party: | | (4) | Date Filed |

| *** Exercise Your Right to Vote *** IMPORTANT NOTICE Regarding the

Availability of Proxy Materials
	Meeting
Information
	Meeting
Type: Annual Meeting
LEXICON
PHARMACEUTICALS, INC.	For holders as of: March 01,
2010
	Date: April 29,
2010	Time: 8:00 AM
CDT
	Location:	Lexicon
Pharmaceuticals, Inc.
		8800 Technology Forest
Place
		The
Woodlands, TX
	You are receiving this communication because you hold shares in the
above named company .
LEXICON
PHARMACEUTICALS, INC 8800 TECHNOLOGY FOREST
PLACE THE WOODLANDS, TX
77381-4287	This is not a ballot.
You cannot use this notice to vote these shares. This communication
presents only an overview of the more complete proxy materials that are
available to you on the Internet. You may view the proxy materials
online at www.proxyvote.com or
easily request a paper copy (see reverse side)
	We
encourage you to access and review all of the important information
contained in the proxy materials before voting.
	See the reverse side of this notice to obtain proxy materials and voting
instructions.

| — BEFORE

YOU VOTE —
How
to Access the Proxy Materials

| Proxy

Materials Available to VIEW or RECEIVE:
1.
Notice & Proxy Statement	2.
Annual Report
How to View
Online:
Have the 12-Digit Control
Number available (located on the following page) and visit: www.proxyvote.com
How to
Request and Receive a PAPER or E-MAIL Copy:
If
you want to receive a paper or e-mail copy of these documents, you must
request one. There is NO charge for requesting a copy. Please choose one
of the following methods to make your request:
1) BY
INTERNET:	www.proxyvote.com
2) BY
TELEPHONE:	1-800-579-1639
3) BY
EMAIL*:	sendmaterials@proxyvote.com
*
If requesting materials by e-mail, please send a blank e-mail with the
12-Digit Control Number (located on the following page) in the subject
line.
Requests, instructions and
other inquiries sent to this e-mail address will NOT be forwarded to your
investment advisor. Please make the request as instructed above on or
before April 15, 2010 to facilitate timely delivery.

| — HOW

TO VOTE —
Please Choose One of The Following Voting
Methods

| Vote in Person: Many shareholder meetings have attendance requirements including, but not limited to, the possession of an attendance ticket issued by the entity holding the meeting. Please check the meeting materials for any special requirements for meeting attendance. At the Meeting you will need to

request a ballot to vote these shares.
Vote by Internet: To vote now by Internet, go to www.proxyvote.com .
Have the 12 Digit Control Number available and follow the
instructions.
Vote
by Mail: You can vote by mail by
requesting a paper copy of the materials, which will include a proxy
card.

Voting items

The Board of Directors recommends that you vote FOR the following.

1. Election of Directors

Nominees:

1. Raymond Debbane 02) Robert J. Lefkowitz, MD 03) Alan S. Nies, MD

The Board of Directors recommneds you vote FOR the following proposal(s):

1. Ratification and approval of the appointment of Ernst & Young LLP as the Company's independent auditors for the fiscal year ending December 31, 2010.

NOTE: In their discretion, upon such other matters that may properly come before the meeting or any adjournment or adjournments thereof.