LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2017

May 1, 2017

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC. (LXRX)
CIK: 0001062822
Period of Report: 2017-04-28

Reporting Person: LEFKOWITZ ROBERT J MD (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2017-04-28	Common Stock	A	1281	—	Acquired	10338	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2017-04-28	Stock Option (Right to Buy)	$15.61	A	2857	Acquired	2027-04-28	Common Stock (2857)	Direct

Footnotes

F1: Option vests with respect to 1/12th of the shares subject to the option for each month of service following the date of grant.