LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2016

May 2, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC. (LXRX)
CIK: 0001062822
Period of Report: 2016-04-29

Reporting Person: Palantoni Frank (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2016-04-29	Common Stock	A	1432	—	Acquired	9057	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2016-04-29	Stock Option (Right to Buy)	$13.96	A	2857	Acquired	2026-04-29	Common Stock (2857)	Direct

Holdings (Derivative)

Security	Exercise Price	Expiration	Underlying	Shares	Ownership
Stock Option (Right to Buy)	$26.39	2017-04-26	Common Stock (1428)	1428	Direct
Stock Option (Right to Buy)	$15.40	2018-04-24	Common Stock (1428)	1428	Direct
Stock Option (Right to Buy)	$6.93	2019-04-24	Common Stock (1428)	1428	Direct
Stock Option (Right to Buy)	$13.86	2023-05-10	Common Stock (2857)	2857	Direct
Stock Option (Right to Buy)	$10.78	2020-04-30	Common Stock (1428)	1428	Direct
Stock Option (Right to Buy)	$11.83	2021-04-29	Common Stock (1428)	1428	Direct
Stock Option (Right to Buy)	$11.90	2022-04-27	Common Stock (2857)	2857	Direct
Stock Option (Right to Buy)	$10.92	2024-04-25	Common Stock (2857)	2857	Direct
Stock Option (Right to Buy)	$7.49	2025-04-24	Common Stock (2857)	2857	Direct

Footnotes

F1: Option vests with respect to 1/12th of the shares subject to the option for each month of service following the date of grant.

F2: Option vests with respect to 1/12th of the shares subject to the option for each month of service following the date of grant.