LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2016

May 23, 2016

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC. (LXRX)
CIK: 0001062822
Period of Report: 2016-05-23

Reporting Person: Tessmer James F (VP, Finance & Accounting)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2016-05-23	Common Stock	M	6000	$6.23	Acquired	21946	Direct
2016-05-23	Common Stock	S	6000	$13.00	Disposed	15946	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2016-05-23	Stock Option (Right to Buy)	$6.23	M	6000	Disposed	2025-02-05	Common Stock (6000)	Direct

Footnotes

F1: Effected pursuant to a Rule 10b5-1 trading plan adopted by Mr. Tessmer on May 16, 2016.

F2: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/5/16) and vests 1/48th per month for each month of service thereafter.