LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2013

May 13, 2013

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC./DE (LXRX)
CIK: 0001062822
Period of Report: 2013-05-10

Reporting Person: BARKER SAM L (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2013-05-10	Common Stock	A	10101	—	Acquired	121865	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2013-05-10	Stock Option (Right to Buy)	$1.98	A	20000	Acquired	2023-05-10	Common Stock (20000)	Direct

Footnotes

F1: Option vests with respect to 1/12th of the shares subject to the option for each month of service following the date of grant.