LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2012

Apr 10, 2012

SEC Form 3 — Initial Statement of Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC./DE (LXRX)
CIK: 0001062822
Period of Report: 2012-03-31

Reporting Person: ARTAL INTERNATIONAL SCA (Director, 10% Owner)
Reporting Person: Artal International Management S.A. (Director, 10% Owner)
Reporting Person: ARTAL GROUP S A (Director, 10% Owner)
Reporting Person: WESTEND SA (Director, 10% Owner)
Reporting Person: Stichting Administratiekantoor Westend (Director, 10% Owner)
Reporting Person: Minne Pascal (Director, 10% Owner)

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	250372135	Indirect

Footnotes

F1: 244,818,843 of the reported shares of Issuer common stock are owned directly by Invus, L.P. and 5,553,292 of the reported shares of Issuer common stock are owned directly by Invus Public Equities, L.P. Invus Advisors, L.L.C. is the general partner of Invus, L.P., and Invus Public Equities Advisors, LLC is the general partner of Invus Public Equities, L.P. Artal International S.C.A. is the managing member of each of Invus Advisors, L.L.C. and Invus Public Equities Advisors, LLC. Artal International Management S.A. is the general partner of Artal International S.C.A., which is a wholly owned subsidiary of Artal Group S.A., which is a wholly owned subsidiary of Westend S.A., which is a wholly owned subsidiary of Stichting Administratiekantoor Westend (the "Stichting"). (Continued in Footnote 2)

F2: Mr. Pascal Minne is the sole member of the board of the Stichting. Accordingly, each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne may be deemed to be indirect beneficial owners of the reported securities. Each of Artal International S.C.A., Artal International Management S.A., Artal Group S.A., Westend S.A., the Stichting and Mr. Minne disclaims beneficial ownership of such securities, except to the extent of its or his pecuniary interest therein.