LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2012

May 1, 2012

SEC Form 4/A — Form 4/A

Issuer: LEXICON PHARMACEUTICALS, INC./DE (LXRX)
CIK: 0001062822
Period of Report: 2012-04-27

Reporting Person: DEBBANE RAYMOND (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2012-04-27	Common Stock	A	11764	—	Acquired	11764	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2012-04-27	Stock Option (Right to Buy)	$1.70	A	20000	Acquired	2022-04-27	Common Stock (20000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	29782609	Indirect

Footnotes

F1: This amendment to the Form 4 filed by Mr. Debbane on April 27, 2012 (the "Form 4") is being filed solely to correct the amount of Issuer common stock reported as beneficially owned by Mr. Debbane in Table I of the Form 4. As described in Item 4 of Amendment No. 10 to the Schedule 13D filed by Invus, L.P. and certain other reporting persons with respect to the Issuer on April 10, 2012, Mr. Debbane no longer has voting or dispositive power over the shares of Issuer common stock held of record by Invus, L.P. and Invus Public Equities, L.P. as a result of an internal reorganization of certain entities affiliated with Mr. Debbane. Thus, Table I of the Form 4 should not have attributed to Mr. Debbane beneficial ownership of the shares of Issuer common stock held of record by Invus, L.P. and Invus Public Equities, L.P., and accordingly, this amendment has been filed to correct such error.

F2: Option vests with respect to 1/12th of the shares subject to the option for each month of service following the date of grant.