LEXICON PHARMACEUTICALS, INC. — Director's Dealing 2009

Feb 17, 2009

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: LEXICON PHARMACEUTICALS, INC./DE (LXRX)
CIK: 0001062822
Period of Report: 2009-02-12

Reporting Person: MAIN ALAN J (EVP, Pharmaceutical Research)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2009-02-12	Common Stock	A	44800	—	Acquired	44800.00	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2009-02-12	Employee Stock Option (right to buy)	$1.45	A	325000	Acquired	2019-02-12	Common Stock (325000.00)	Direct

Footnotes

F1: Option vests with respect to 25% of the shares subject to the option on the first anniversary of grant (2/12/2010) and vests 1/48th per month for each month of service thereafter.