Knight Therapeutics Inc. — Proxy Solicitation & Information Statement 2026

Apr 4, 2026

NOTICE IS HEREBY GIVEN that the Annual General Meeting (the "Meeting") of the shareholders of Knight Therapeutics Inc. (the "Corporation" or "Knight") will be held:

Where:

Virtual-only meeting via live audio webcast at https://meetnow.global/MMT6CWA

When:

Wednesday, May 6, 2026, at 9:00 a.m. (Eastern time)

The following items of business will be covered, as more fully described in the accompanying management information circular (the "Information Circular"):

1. Receive the audited consolidated financial statements of the Corporation for the financial year ended December 31, 2025, together with the auditors' report thereon;
2. Elect the directors of the Corporation for the ensuing year;
3. Re-appoint Ernst & Young LLP as auditors of the Corporation and authorize the Board of Directors of the Corporation to fix the auditors' remuneration; and
4. Transact such other business as may properly come before the Meeting or any adjournment thereof.

Virtual-Only Format

The Corporation has elected to hold the Meeting in a virtual-only format via live audio webcast. The Corporation believes that this format encourages broader participation from shareholders, regardless of their geographic location, and provides all shareholders with an equal opportunity to engage in the Meeting. We remain committed to encouraging and promoting shareholder participation and facilitating the ability of all shareholders to exercise their rights to vote, attend and participate in the Meeting. We believe that the use of technology-enhanced shareholder communications makes the Meeting accessible and engaging for all participants. The selected platform allows shareholders to attend the Meeting via a single sign-on process, follow proceedings in their preferred language, and ask questions. Shareholders may also submit questions in writing prior to the Meeting by emailing IR@knighttx.com. The Corporation will continue to provide additional opportunities to engage with its shareholders throughout the year, as will be described in the Information Circular.

Registered shareholders and duly appointed proxyholders will be able to attend, submit questions and vote at the Meeting online at https://meetnow.global/MMT6CWA. Non-registered (beneficial) shareholders who have not duly appointed themselves as proxyholders will be able to attend the Meeting as guests; however, guests will not be able to vote or submit questions during the Meeting.

Whether or not you are able to attend the Meeting virtually, shareholders are encouraged to vote as soon as possible, either electronically, by telephone, by email or in writing, by following the instructions set out in the form of proxy or voting instruction form, as applicable, which accompanies this Notice of Meeting. Proxies must be received by the Corporation's transfer agent, Computershare Investor Services Inc. ("Computershare"), at 320 Bay Street, 14th Floor, Toronto, Ontario M5H 4A6, Attention: Investor Services, Fax: 1-866-249-7775, not later than 9:00 a.m.(Eastern time) on May 4, 2026 (or no later than 48 hours, excluding Saturdays, Sundays and holidays, before any reconvened meeting if the Meeting is adjourned or postponed). The deadline for the deposit of proxies may be waived or extended by the Chair of the Meeting at his or her discretion, without notice.

A French version of the Information Circular is or will be made available under the Corporation's profile on SEDAR+ at www.sedarplus.ca prior to the Meeting. Une version française de la circulaire d'information de la direction sera disponible sous le profil de la société sur SEDAR+ à l'adresse www.sedarplus.ca avant l'assemblée.

Since 2024, the Corporation has been required to file an annual report under the Fighting Against Forced Labour and Child Labour in Supply Chains Act (Canada), outlining the steps it has taken to prevent and mitigate the risk of forced labour or child labour within its business and supply chains. The report for the fiscal year ended December 31, 2025 is available on the Corporation's website at www.knighttx.com and under the Corporation's profile on SEDAR+ at www.sedarplus.ca.

Montréal, Québec, April 3, 2026

(s) Samira Sakhia

Samira Sakhia, M.B.A

President and Chief Executive Officer

By order of the Board of Directors,

(s) Jonathan Ross Goodman

Jonathan Ross Goodman, B.A., LL.B., M.B.A.

Executive Chairman of the Board of Directors