IONIS PHARMACEUTICALS INC — Director's Dealing 2020

Jul 6, 2020

SEC Form 4 — Statement of Changes in Beneficial Ownership

Issuer: IONIS PHARMACEUTICALS INC (IONS)
CIK: 0000874015
Period of Report: 2020-07-01

Reporting Person: MUTO FREDERICK T (Director)

Non-Derivative Transactions

Date	Security	Code	Shares	Price	A/D	Holdings After	Ownership
2020-07-01	Common Stock	M	666	—	Acquired	28349	Direct
2020-07-01	Common Stock	M	1778	—	Acquired	30127	Direct
2020-07-02	Common Stock	M	889	—	Acquired	31016	Direct
2020-07-06	Common Stock	M	667	—	Acquired	31683	Direct

Derivative Transactions

Date	Security	Exercise Price	Code	Shares	A/D	Expiration	Underlying	Ownership
2020-07-01	Restricted Stock Units	$	M	666	Disposed		Common Stock (666)	Direct
2020-07-01	Restricted Stock Units	$	M	1778	Disposed		Common Stock (1778)	Direct
2020-07-02	Restricted Stock Units	$	M	889	Disposed		Common Stock (889)	Direct
2020-07-06	Restricted Stock Units	$	M	667	Disposed		Common Stock (667)	Direct
2020-07-01	Restricted Stock Units	$0	A	5333	Acquired		Common Stock (5333)	Direct
2020-07-01	Director Stock Option (right to buy)	$60.2	A	12000	Acquired	2030-06-30	Common Stock (12000)	Direct

Holdings (Non-Derivative)

Security	Shares	Ownership
Common Stock	1500	Indirect

Footnotes

F1: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F2: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F3: These Restricted Stock Units vest in four equal annual installments. Upon vesting, the Restricted Stock Units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4: Grant of July 1, 2020 to reporting person of Restricted Stock Unit award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. These Restricted Stock Units vest
100% on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier, and will be delivered to the reporting person on the July 15th
following the vesting date. The Restricted Stock Unit is vested as to 0 shares on July 1, 2020.

F5: Grant of July 1, 2020 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. 100% of the shares subject to the option vest and
become exercisable on either the first anniversary of the date of grant or the next regularly scheduled annual meeting of stockholders of the Company, whichever occurs earlier. The option is exercisable to 0 shares on July 1,
2020.